Evidence map›Paper›PMID 42366102›Full record

ArticleEndocrine journal2026

Associations of stress hormones, autonomic function, and endothelial function in patients with diabetes.

Takanobu Saheki, Keisuke Takahashi, Eri Harada, Takafumi Yoshimura, Toshihiro Kobayashi, Kensaku Fukunaga, Hitomi Imachi, Koji Murao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Takanobu SahekiDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.ORCID http://orcid.org/0009-0005-8909-9821
Keisuke TakahashiDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
Eri HaradaDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
Takafumi YoshimuraDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
Toshihiro KobayashiDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.ORCID http://orcid.org/0000-0003-2038-7970
Kensaku FukunagaDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.ORCID http://orcid.org/0000-0002-0012-5263
Hitomi ImachiDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
Koji MuraoDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.ORCID http://orcid.org/0000-0002-7335-7196

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelial dysfunction is an early feature of diabetic vascular injury. Stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis, together with autonomic imbalance, may contribute to endothelial dysfunction. However, its clinical relevance in diabetes remains to be fully elucidated. We retrospectively analyzed 60 patients with diabetes who underwent both flow-mediated dilation (FMD) of the brachial artery and the coefficient of variation of the R-R interval (CVRR) measurements. The primary objective was to examine the association between FMD and stress-related hormones, including adrenocorticotropic hormone (ACTH) and cortisol. The secondary objective was to evaluate the association with autonomic function (CVRR) and other clinical variables. Mean FMD was 5.10 ± 2.32%. FMD correlated inversely with ACTH (r = -0.41, p = 0.0015) and cortisol (r = -0.39, p = 0.0024), and positively with CVRR (r = 0.49, p < 0.001). These relationships were stronger in patients with BMI ≥27 kg/m

Indexed as

Adrenocorticotropic HormoneAutonomic Nervous SystemDiabetes Mellitus, Type 2Endothelium, VascularHydrocortisoneAgedBrachial ArteryFemaleHumansHypothalamo-Hypophyseal SystemMaleMiddle AgedPituitary-Adrenal SystemRetrospective StudiesVasodilationAdrenocorticotropic HormoneHydrocortisoneAutonomic nervous systemDiabetes mellitusEndothelial dysfunctionFlow-mediated dilationHypothalamic–pituitary–adrenal axis

Identifiers

PMID42366102
PMCPMC13671839

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.