Evidence map›Paper›PMID 42366061›Full record

ArticleThe Journal of veterinary medical science2026

Association of glycolysis-related protein expression with prognosis in Canine Pulmonary Adenocarcinoma.

Ami Aoyama, Taiki Kato, Masanao Ichimata, Kosuke Kobayashi, Masashi Sakurai, Yumiko Kagawa, Hiroto Toyoda, Ryuzo Katayama, Kei Harada, Eri Fukazawa and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of veterinary medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ami AoyamaLaboratory of Molecular Diagnostics and Therapeutics, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.
Taiki KatoLaboratory of Molecular Diagnostics and Therapeutics, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.
Masanao IchimataLaboratory of Molecular Diagnostics and Therapeutics, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.
Kosuke KobayashiFaculty of Veterinary Medicine, Okayama University of Science, Ehime, Japan.
Masashi SakuraiLaboratory of Veterinary Pathology, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.
Yumiko KagawaNorth Lab., Hokkaido, Japan.
Hiroto ToyodaJapan Small Animal Cancer Center, Public Interest Incorporated Foundation Japan Small Animal Medical Center, Saitama, Japan.
Ryuzo KatayamaJapan Small Animal Cancer Center, Public Interest Incorporated Foundation Japan Small Animal Medical Center, Saitama, Japan.
Kei HaradaJapan Small Animal Cancer Center, Public Interest Incorporated Foundation Japan Small Animal Medical Center, Saitama, Japan.
Eri FukazawaJapan Small Animal Cancer Center, Public Interest Incorporated Foundation Japan Small Animal Medical Center, Saitama, Japan.
Fukiko MatsuyamaJapan Small Animal Cancer Center, Public Interest Incorporated Foundation Japan Small Animal Medical Center, Saitama, Japan.
Tetsuya KobayashiJapan Small Animal Cancer Center, Public Interest Incorporated Foundation Japan Small Animal Medical Center, Saitama, Japan.
Takuya MizunoLaboratory of Molecular Diagnostics and Therapeutics, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.
Masaya IgaseLaboratory of Molecular Diagnostics and Therapeutics, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Canine pulmonary adenocarcinoma (CPAC) is a rare, aggressive tumor with no established prognostic molecular biomarkers. The expression of monocarboxylate transporter 4 (MCT4) and glucose transporter 1 (GLUT1), key glycolysis-related proteins, is induced by hypoxia and is generally associated with poor prognosis in human pulmonary adenocarcinoma; however, their clinical significance in dogs remains unclear. This study investigated the expression of MCT4 and GLUT1 in 61 CPAC cases. Immunohistochemistry revealed significantly higher MCT4 and GLUT1 expression in tumors compared with normal lung tissues. High expression of both proteins was associated with lymph node metastasis. Kaplan-Meier analysis showed that high MCT4 expression was associated with prolonged overall survival, while GLUT1 showed no prognostic impact. However, MCT4 was not retained as an independent prognostic factor in multivariable Cox proportional hazards analysis. These results suggest that MCT4 and GLUT1 are upregulated in CPAC and may have distinct biological and clinical significance compared with human pulmonary adenocarcinoma.

Indexed as

AdenocarcinomaAdenocarcinoma of LungDog DiseasesGlucose Transporter Type 1Lung NeoplasmsMonocarboxylic Acid TransportersMuscle ProteinsAnimalsBiomarkers, TumorDogsFemaleGene Expression Regulation, NeoplasticGlycolysisImmunohistochemistryLymphatic MetastasisMaleBiomarkers, TumorGlucose Transporter Type 1Monocarboxylic Acid TransportersMuscle Proteinsadenocarcinoma of lungcanineglycolysishypoxiaimmunohistochemistry

Identifiers

PMID42366061
PMCPMC13616605

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.