ArticleHearing research2026
Repopulating microglia recapitulate developmental characteristics during a period of auditory circuit recovery.
Article in Hearing research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Precision in auditory brainstem circuitry is essential for sound localization and higher levels of processing. Assembly of this circuitry requires specialized developmental mechanisms, including multipartite signaling between neurons and glia. Microglia populate the developing auditory brainstem nuclei lateromedially, appearing first in the ventral cochlear nucleus, and later in the medial nucleus of the trapezoid body. Microglia increase in number just after hearing onset, then reduce to stable levels following a period of synaptic refinement. We previously showed that early microglia depletion impaired synaptic pruning and auditory brainstem responses. Microglial repopulation, which occurred significantly later than normal development, restored these deficits. This finding suggests that microglia take on developmental roles to reinstate circuit assembly outside of the normal development timeframe. To begin unravelling this phenomenon, we compared morphology and phagocytosis in developing and repopulating microglia. We used CX3CR1+/EGFP mice and characterized individual microglia throughout the postnatal period in control mice and in mice with repopulating microglia. We tested whether repopulating microglia recapitulate developmental qualities by measuring microglial surface area, volume, branching, and lysosomes. We found that infiltrating microglia acquire developmental properties during synaptic refinement, even beyond the normal auditory development timeframe.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.