Evidence map›Paper›PMID 42365463›Full record

ArticleJournal of immunology research2026

A Novel Magnetically Targeted Intramedullary (MagIC-TI) Xenograft Model for Precise Leukemia Modeling and Drug Resistance Evaluation in the Bone Marrow Niche.

Qiusui Mai, Taosong Liu, Luxia Tang, Lihan Dai, Siyi Li, Jingyi Guo, Wen Xia, Lingxi Chen, Jiabao Wu, Jiawei Rong and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qiusui MaiDepartment of Blood Transfusion, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, China, sysu.edu.cn.ORCID https://orcid.org/0000-0003-3095-8132
Taosong LiuFirst School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China, fimmu.com.ORCID https://orcid.org/0009-0006-1166-9430
Luxia TangSouthern Medical University, Guangzhou, 510515, China, fimmu.com.ORCID https://orcid.org/0009-0003-0326-1927
Lihan DaiFirst School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China, fimmu.com.ORCID https://orcid.org/0009-0004-4310-4376
Siyi LiFirst School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China, fimmu.com.ORCID https://orcid.org/0009-0005-3599-1590
Jingyi GuoFirst School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China, fimmu.com.ORCID https://orcid.org/0009-0007-2004-0404
Wen XiaFirst School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China, fimmu.com.ORCID https://orcid.org/0009-0002-1884-4183
Lingxi ChenSchool of Stomatology, Southern Medical University, Guangzhou, 510515, China, fimmu.com.ORCID https://orcid.org/0009-0005-9458-9948
Jiabao WuFirst School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China, fimmu.com.ORCID https://orcid.org/0009-0009-7717-5988
Jiawei RongSchool of Stomatology, Southern Medical University, Guangzhou, 510515, China, fimmu.com.ORCID https://orcid.org/0009-0008-3686-064X
Weishen ZhangGuangzhou Maishi Biotechnology Co., Ltd., Guangzhou, 510515, China.ORCID https://orcid.org/0009-0002-3052-3008
Jiaxing ZhangGuangzhou Maishi Biotechnology Co., Ltd., Guangzhou, 510515, China.ORCID https://orcid.org/0009-0000-2238-3549
Xiaojun XuDepartment of Blood Transfusion, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, China, sysu.edu.cn.ORCID https://orcid.org/0000-0001-5030-7201
Qianli JiangClinical Trial Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China, fimmu.com.ORCID https://orcid.org/0000-0001-9308-0043

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2016A030313585Basic and Applied Basic Research Foundation of Guangdong Province 2018A030313647Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515110236Innovation Program for Undergraduates of Southern Medical University 202412121329Innovation Program for Undergraduates of Southern Medical University 202412121343Innovation Program for Undergraduates of Southern Medical University 202612121029Research Start-up Fund of Post-doctoral of SAHSYSU ZSQYRSFPD0077
6 · The paper itself

Abstract

Acute myeloid leukemia (AML) remains a therapeutic challenge due to drug resistance and relapse, which are often driven by the protective bone marrow (BM) niche. Conventional xenograft models fail to adequately recapitulate this niche-specific pathophysiology. To overcome this limitation, a novel magnetically targeted intramedullary (MagIC-TI) xenograft model was developed. Magnetically labeled doxorubicin (DOX)-resistant HL60 cells (Mag-Re) were injected into the femurs of NSG (nonobese diabetic [NOD] Cg-Prkdc

Indexed as

Bone MarrowDrug Resistance, NeoplasmLeukemia, Myeloid, AcuteAnimalsDisease Models, AnimalDoxorubicinHL-60 CellsHumansMagneticsMiceMice, Inbred NODXenograft Model Antitumor AssaysDoxorubicinacute myeloid leukemia (AML)bone marrow nichedrug resistanceminimal residues diseases (MRD)xenograft model

Identifiers

PMID42365463
PMCPMC13310384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.