Evidence map›Paper›PMID 42365453›Full record

ArticleCanadian respiratory journal2026

Cortex Mori Radicis Mitigates Inflammation and Fibrosis in Pulmonary Fibrosis Through PI3K/AKT Pathway Suppression.

Tianxiang Qi, Bingfeng Ma, Yuanyuan Peng, Yafeng Liu, Jianqiang Guo, Xingyu Yang, Xuansheng Ding, Dingfei Ren, Dong Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tianxiang QiThe First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), School of Medicine, Anhui University of Science and Technology, Huainan, China, aust.edu.cn.ORCID https://orcid.org/0009-0004-9020-9349
Bingfeng MaThe First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), School of Medicine, Anhui University of Science and Technology, Huainan, China, aust.edu.cn.
Yuanyuan PengThe First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), School of Medicine, Anhui University of Science and Technology, Huainan, China, aust.edu.cn.
Yafeng LiuThe First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), School of Medicine, Anhui University of Science and Technology, Huainan, China, aust.edu.cn.
Jianqiang GuoThe First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), School of Medicine, Anhui University of Science and Technology, Huainan, China, aust.edu.cn.
Xingyu YangThe First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), School of Medicine, Anhui University of Science and Technology, Huainan, China, aust.edu.cn.
Xuansheng DingThe First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), School of Medicine, Anhui University of Science and Technology, Huainan, China, aust.edu.cn.ORCID https://orcid.org/0000-0002-5585-9010
Dingfei RenOccupational Control Hospital of Huaihe Energy Group, Huainan, China.
Dong HuAnhui Occupational Health and Safety Engineering Laboratory, School of Medicine, Anhui University of Science and Technology, Huainan, China, aust.edu.cn.ORCID https://orcid.org/0000-0002-8995-4729

Funding

Clinical and Translational Research Project of Anhui Province 202427b10020102Clinical and Translational Research Project of Anhui Province 202427b10020117Clinical and Translational Research Project of Anhui Province 202427bl0020087Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes AYZJSGCLK202402002Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes AYZJSGXLK202401002Province Science and Technology Innovation Major Project Plan 202423l10050053
6 · The paper itself

Abstract

Early in the pathogenesis of pulmonary fibrosis (PF), there are multiple inflammatory cell infiltrations in the damaged lung tissue. When lung injury persists, inflammatory cytokines prompt local fibroblasts migration and hyperproliferation, triggering abnormal deposition of extracellular matrix in the lung interstitium. This excessive repair leads to interstitial cell reorganization, triggering lung tissue fibrosis and further activation of inflammatory cells. Therefore, modulation of inflammatory mediators is of great significance in the treatment and prevention in the process of fibrosis. Cortex Mori Radicis (CMR) is a traditional Chinese herb with anti-inflammatory and antifibrotic properties. In this study, we investigated the therapeutic effects of CMR on bleomycin-induced PF using in vivo and in vitro models. In vivo experiments showed that CMR treatment significantly reduced inflammation, attenuated fibrosis, and alleviated lung function decline. In vitro, CMR inhibited migration, proliferation, and epithelial-mesenchymal transition (EMT) in A549 lung epithelial cells. Network pharmacological analysis identified 25 bioactive components and 10 key therapeutic targets in CMR, with the PI3K/AKT signaling pathway emerging as the core regulatory mechanism. Subsequent in vivo validation confirmed that CMR could inhibit the activation of the PI3K/AKT pathway. In conclusion, CMR exerts protective effects against PF by modulating the PI3K/AKT pathway, thereby attenuating inflammation and fibrotic remodeling. This study provides both pharmacodynamic evidence and mechanistic insight supporting the clinical potential of CMR and underscores the advantages of multitargeted intervention strategies offered by traditional Chinese medicine in the treatment of PF.

Indexed as

Drugs, Chinese HerbalPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPulmonary FibrosisA549 CellsAnimalsBleomycinCell MovementCell ProliferationDisease Models, AnimalEpithelial-Mesenchymal TransitionHumansInflammationMaleMiceMice, Inbred C57BLBleomycinDrugs, Chinese HerbalPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktCortex Mori Radicisherbal medicinemolecular dockingnetwork pharmacologypulmonary fibrosis

Identifiers

PMID42365453
PMCPMC13310380

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.