Evidence map›Paper›PMID 42365435›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2026

Long-term functional synaptic integration of genome-edited retinal organoids in a primate model of macular degeneration.

Atsuta Ozaki, Akihiro Kawai, Ryutaro Akiba, Satoko Okayama, Nobuhiko Ohno, Keisuke Kajita, Tomohiro Masuda, Satoshi Yokota, Shin-Ichiro Ito, Du Peiyan and 6 more

Abstract read
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In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Atsuta OzakiKobe City Eye Hospital, Kobe 650-0047, Japan; Cell and Gene Therapy in Ophthalmology Laboratory, BZP, RIKEN, Wako, Saitama 351-0198, Japan; Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu 514-8507, Japan.
Akihiro KawaiOphthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Ryutaro AkibaOphthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Satoko OkayamaLaboratory for Ultrastructural Research, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan.
Nobuhiko OhnoDivision of Ultrastructural Research, National Institute for Physiological Sciences, Okazaki 444-8787, Japan; Department of Anatomy, Division of Histology and Cell Biology, Jichi Medical University, Shimotsuke 329-0498, Japan.
Keisuke KajitaKobe City Eye Hospital, Kobe 650-0047, Japan; Department of Ophthalmology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
Tomohiro MasudaKobe City Eye Hospital, Kobe 650-0047, Japan.
Satoshi YokotaKobe City Eye Hospital, Kobe 650-0047, Japan; Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan.
Shin-Ichiro ItoKobe City Eye Hospital, Kobe 650-0047, Japan; Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan.
Du PeiyanOphthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Kenta OnoueLaboratory for Ultrastructural Research, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan.
Shigenobu YonemuraLaboratory for Ultrastructural Research, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan; Department of Cell Biology, Tokushima University Graduate School of Medicine, Tokushima 770-8503, Japan.
Mineo KondoDepartment of Ophthalmology, Mie University Graduate School of Medicine, Tsu 514-8507, Japan.
Yasuo KurimotoKobe City Eye Hospital, Kobe 650-0047, Japan; Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan.
Yingbin FuCullen Eye Institute, Baylor College of Medicine, Houston, TX 77030, USA.
Michiko MandaiKobe City Eye Hospital, Kobe 650-0047, Japan; Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan. Electronic address: e_lab.mandai@kcho.jp.

Funding

A two-pronged approach to generating novel models of photoreceptor degeneration for regenerative cell therapyU24EY033272 · NEI · BAYLOR COLLEGE OF MEDICINE · PI Yingbin Fu · 2021 to 2026
$3.8M
NEI NIH HHS U24 EY033272
6 · The paper itself

Abstract

Retinal organoids represent a promising regenerative strategy for restoring vision in retinal degenerative diseases, but the capacity of host cone bipolar cells in the primate macula to rewire with transplanted photoreceptors has not been established. In this study, we transplanted genome-edited ISL1

Indexed as

Macular DegenerationOrganoidsRetinaSynapsesAnimalsDisease Models, AnimalElectroretinographyHumansLIM-Homeodomain ProteinsRetinal Bipolar CellsTranscription Factorsinsulin gene enhancer binding protein Isl-1LIM-Homeodomain ProteinsTranscription Factorsbipolar cellselectrophysiologyhost-graft synapsesmacular degenerationnon-human primatephotoreceptor cellsregenerative therapyretinal organoidretinal plasticitytransplantation

Identifiers

PMID42365435
PMCPMC13555564

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.