Trial reportJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026
Efficacy and safety of the Chinese herbal medicine Xiao'er Niuhuang antipyretic plaster for treating fever in children with acute upper respiratory tract infection with wind-heat syndrome: a multicenter, randomized, double-blind, controlled clinical trial.
Trial report in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate the efficacy and safety of Xiao'er Niuhuang antipyretic plaster in treating fever associated with acute upper respiratory tract infection (AURI) accompanied by wind-heat syndrome in children.
methodsA total of 464 pediatric patients diagnosed with AURI and wind-heat syndrome were enrolled. Participants were stratified into two age subgroups (1-2 years and 3-5 years) and then randomly assigned in a 3:1 ratio to receive either the Xiao'er Niuhuang antipyretic plaster or an extremely low-dose control plaster. The primary outcome was the time to onset of fever reduction. Safety assessments included monitoring of vital signs, laboratory tests (complete blood count, urinalysis, stool routine, and liver and kidney function), electrocardiogram, and local skin reactions.
resultsThe median time to onset of antipyretic effect was significantly shorter in the Xiao'er Niuhuang antipyretic plaster group than in the control group (2.53 h
conclusionXiao'er Niuhuang antipyretic plaster is an effective and safe treatment for fever in children with AURI and wind-heat syndrome.
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