Evidence map›Paper›PMID 42365407›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026

Effect of moxibustion at Zusanli (ST36) on beclin 1-solute carrier family 7 member 11 gene ferroptosis-related proteins in synovial inflammation of rats with rheumatoid arthritis.

Hao Feng, Sang Jiajia, Peng Chuanyu, H U Jun, W U Zijian, H U Ling, G U Yihuang

Abstract read
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Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Hao FengSchool of Acupuncture-Moxibustion and Tuina, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Sang JiajiaDepartment of Tuina, the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine/Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing 210029, China.
Peng ChuanyuSchool of Acupuncture-Moxibustion and Tuina, Anhui University of Chinese Medicine, Hefei 230038, China.
H U JunSchool of Acupuncture-Moxibustion and Tuina, Nanjing University of Chinese Medicine, Nanjing 210023, China.
W U ZijianInstitute of Acupuncture and Meridian, Anhui Academy of Traditional Chinese Medicine, Hefei 230038, China.
H U LingInstitute of Acupuncture and Meridian, Anhui Academy of Traditional Chinese Medicine, Hefei 230038, China.
G U YihuangSchool of Acupuncture-Moxibustion and Tuina, Nanjing University of Chinese Medicine, Nanjing 210023, China.

Funding

Natural Science Foundation-funded Project: Autophagy-dependent Ferroptosis of Fibroblast-like Synoviocytes Induced by Recombinant beclin 1-Solute Carrier Family 7 Member 11 Gene in the Mechanism of Moxibustion in Treating Rheumatoid Arthritis 82274645
6 · The paper itself

Abstract

objectiveTo investigate the effects of moxibustion at Zusanli (ST36) on ferroptosis-related proteins in synovial inflammation of rats with rheumatoid arthritis (RA) and verify the mechanism by cell experiments.

methodsA RA rat model was established using a "disease-syndrome integration" modeling method. The rats were randomly divided into a blank control group (Control group) and a model replication group. Rats with successfully replicated RA models were further divided into a model control group (RA group) and a moxibustion treatment group (RA + Mox group). After intervention, the rats' ankle swelling degree and small animal ultrasound examination were conducted and synovial tissue was examined for pathology, lipid reactive oxygen species (ROS) detection, ferrous ion Fe

results(a) Compared to Control group rats, RA rats showed significantly increased footpad swelling (

conclusionMoxibustion at Zusanli (ST36) suggests a potential to relieve footpad swelling and synovial inflammation in RA rats, alleviate synovial tissue hyperplasia and thickening. It may induce lipid ROS accumulation in synovial tissue, upregulating Fe

Indexed as

Acupuncture PointsArthritis, RheumatoidFerroptosisMoxibustionSynovial MembraneAnimalsDisease Models, AnimalFemaleHumansMaleRatsRats, Sprague-DawleyReactive Oxygen SpeciesReactive Oxygen Speciesarthritis, rheumatoidferroptosismoxibustionsynovial inflammationZusanli (ST36)

Identifiers

PMID42365407
PMCPMC13266323

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.