ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026
Role of gamma-aminobutyric acid-ergic neurons in the thalamic reticular nucleus in regulating sleep-wake cycles in mice treated with acupuncture for insomnia.
Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo test whether acupuncture improves sleep by enhancing gamma-aminobutyric acid-ergic (GABA) neuronal activity in the thalamic reticular nucleus (TRN).
methodsWe established an animal model using p-chlorophenylalanine (PCPA). We assessed the impact of acupuncture on insomnia through wheel-running activity and sodium pentobarbital-induced sleep tests. Subsequently, the calcium indicator GCaMP6m was injected into the TRN of Vgat-Cre mice, and the activity of GABA neurons in the TRN was analyzed before and after acupuncture using fiber photometry recording. Additionally, cortical electroencephalography (EEG) recordings were compared between groups following chemogenetic inhibition of GABA neurons in the TRN.
resultsFollowing acupuncture, we observed a reduction in sleep latency and an increase in sleep duration in comparison to the PCPA-induced insomnia (
conclusionsAcupuncture activates GABA neurons in the TRN, thereby regulating the sleep-wake cycle in the context of PCPA-induced insomnia.
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