Evidence map›Paper›PMID 42365402›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026

Therapeutic efficacy of Jichuan decoction in slow-transit constipation: focus on gut microbiota modulation.

Wang Xiumin, Lü Lixia, L I Jianghua, Chen Jilan, Tan Cailin, Ding Weijun

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Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Wang XiuminDepartment of General Surgery, Chengdu Second People's Hospital, Chengdu 610021, China.
Lü LixiaDepartment of Endocrinology and Metabolism, Chengdu First People's Hospital, Chengdu 610041, China.
L I JianghuaAntibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, School of Pharmacy, Chengdu University, Chengdu 610106, China.
Chen JilanDepartment of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.
Tan CailinDepartment of Gastroenterology, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine Deyang Hospital, Deyang 618000, China.
Ding WeijunDepartment of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.

Funding

General Project of Sichuan Provincial Administration of Traditional Chinese Medicine: Exploring the Mechanism of Jichuan Decoction in Regulating Intestinal nerve Apoptosis in Slow Transit Constipation Rats Based on the Tumor Necrosis Factor Signaling Pathway 2024MS589National Natural Science Foundation of China: Exploring the Mechanism of Qi-tonifying and Phlegm-eliminating Acupuncture Promoting Intestinal Nerve Precursor Cell Regeneration in Obese Mice Based on the Single-cell RNA-sep Platform 82374176Natural Science Foundation of Sichuan Province: Discovery of "Active Center" Oligosaccharide Fragments in Polysaccharides of Pinellia Ternata and Its Processed Products and Research on Quality Evaluation Techniques and Methods 2022NSFSC0591Project of Sichuan Medical Association: Exploring the Mechanism of Jichuan Decoction in Regulating Intestinal Nerve Apoptosis in Slow Transit Constipation Rats Based on the Glial Cell line-derived Neurotrophic Factor/Phosphoinositide 3-kinase/Protein Kinase B Signaling Pathway S23034Youth Nursery Project of Sichuan Provincial Health Commission: Mechanism Research on miR-491-5p Targeting Akt to Inhibit Intestinal Nerve Apoptosis in the Pathogenesis of Slow Transit Constipation 24QNMP030
6 · The paper itself

Abstract

objectiveTo clarify the therapeutic mechanisms of Jichuan decoction (, JCD) in slow-transit constipation (STC), we focused on its neuromuscular and microbiota-modifying effects.

methodsAn STC mouse model was induced by administering diphenoxylate for 14 consecutive days. The experimental groups included healthy controls (HC), a saline-treated STC model group, a mosapride-treated positive control group (MSP), and JCD-treated groups at different dosages. Gastrointestinal motility was evaluated first by black stool latency and then by colonic 5-hydroxytryptamine and substance P levels. Neural markers were assessed by real-time quantitative reverse transcription polymerase chain reaction, and glial-derived neurotrophic factor (GDNF) and central nervous system specific protein β (S100β) levels were measured via enzyme-linked immunosorbent assay. Histopathological analysis was performed via hematoxylin-eosin and periodic acid-Schiff staining. Microbial profiling was conducted via 16S rRNA sequencing.

resultsJCD treatment improved intestinal motility in STC mice, increased colonic neurotransmitter levels, increased mucosal thickness and goblet cell density, upregulated protein gene product 9.5 and GDNF, downregulated neuronal nitric oxide synthase and S100β, and reversed dysbiosis through the enrichment of Akkermansia muciniphila.

conclusionJCD alleviates STC by restoring enteric nervous system function and gut microbiota homeostasis, indicating its potential for STC management.

Indexed as

ConstipationDrugs, Chinese HerbalGastrointestinal MicrobiomeAnimalsGastrointestinal MotilityGastrointestinal TransitHumansMaleMiceDrugs, Chinese Herbalenteric nervous systemintestinal microbiotaJichuan decoctionslow-transit constipation

Identifiers

PMID42365402
PMCPMC13266331

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.