Evidence map›Paper›PMID 42365401›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026

Yiqi Huoxue formula relieves heart failure with reduced ejection fraction in calcium/calmodulin-dependent protein kinase Ⅱ delta B isoform and calcium/calmodulin-dependent protein kinase Ⅱ delta C isoform transgenic mice by inhibiting myocardial remodeling and enhancing calcium homeostasis.

X U Jianglin, Shi Xiaolu, L I Yan, Zhou Kun, L I Peng, L I Sinai, L U Jinjin, Chen Yajun, Zhan Nannan, Zhang Ruotong and 4 more

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Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

14 authors.

X U JianglinDepartment of Cardiology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Shi XiaoluBeijing Key Laboratory of TCM Basic Research on Prevention and Treatment of Major Disease, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China.
L I YanDepartment of Cardiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
Zhou KunDepartment of Cardiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
L I PengDepartment of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100010, China.
L I SinaiBeijing Institute of Traditional Chinese Medicine, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China.
L U JinjinDepartment of Cardiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
Chen YajunDepartment of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100010, China.
Zhan NannanDepartment of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100010, China.
Zhang RuotongDepartment of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100010, China.
Cheng BairuDepartment of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100010, China.
Lin QianDepartment of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100010, China.
Wan JieDepartment of Cardiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
Liu JingDepartment of Cardiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.

Funding

Fundamental Research Funds for the Central Public Welfare Research Institutes National Traditional Chinese: High-throughput Detection Technology for the Study of Excitation-contraction-coupled Calcium Transport JBGS2021006Investigation on the Mechanism of Yiqi-Huoxue Method on Heart Failurebased on Mitochondrial Calcium/calmodulin-dependent Protein Kinase II Overexpression Mediated Energy Shuttle Disturbance-calcium Homeostasis Disorder 82305170National High Level Chinese Medicine Hospital Clinical Research Funding: Mechanism Study on the Reduction of Post-Percutaneous Coronary Intervention Microvascular Obstruction by Yiqi Liangxue Shengji Formula: Exploring the Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2/Peptidylarginine Deiminase 4 Pathway-mediated Neutrophil Extracellular Trap Formation DFG2RB2024GJR013Natural Science Foundation-funded Project: Underlined Mechanism of Calcium/calmodulin-dependent Protein Kinase II Regulating Heart Failure With Preserved Ejection Fraction and the Effect of Yiqi-Huoxue Formula 81903993
6 · The paper itself

Abstract

objectiveTo confirm the efficacy of Yiqi Huoxue formula (, YQHX) on heart failure with reduced ejection fraction (HFrEF), and elucidate its potential effect on calcium homeostasis.

methodsCardiac specific calcium/calmodulin-dependent protein kinase II delta C isoform (CaMKⅡδC)-overexpression transgenic mice (C-CaMKⅡδC

resultsWe found CaMKⅡδB and CaMKⅡδC transgenic mice showed HFrEF phenotype. YQHX improved the systolic function of the CaMKⅡδB transgenic mice, reduced the cross-sectional area of cardiomyocytes, inhibited the overexpression of CaMKⅡδB and hypertrophy-related genes (B-type natriuretic peptide, myocyte enhancer factor 2, and atrial natriuretic factor), and increased calcium handling protein sarcoendoplasmic reticulum Ca

conclusionOur results suggest that YQHX improved HFrEF by inhibiting CaMKIIδB overexpression, which may be related to reduced expression of hypertrophy-related factors, and increased SERCA2a expression to increase calcium reserve. In addition, YQHX improved HFrEF by inhibiting CaMKIIδC overexpression, which may be related to reduce calcium leakage, and increase SERCA2a expression to increase calcium reserve.

Indexed as

CalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Drugs, Chinese HerbalHeart FailureVentricular RemodelingAnimalsHomeostasisHumansMaleMiceMice, Inbred C57BLMice, TransgenicMyocardiumMyocytes, CardiacStroke VolumeCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Drugs, Chinese Herbalcalcium/calmodulin-dependent protein kinase II delta B isoform overexpressioncalcium/calmodulin-dependent protein kinase II delta C isoform overexpressioncalcium homeostasisheart failure, systolicYiqi Huoxue formula

Identifiers

PMID42365401
PMCPMC13266311

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