ArticleInflammopharmacology2026
Integration of biochemical and pharmacological evaluation of Pistacia lentiscus leaf polysaccharides: evidence for anti-inflammatory and gastroprotective activity.
Article in Inflammopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSulfated polysaccharides have emerged as bioactive macromolecules with potential immunomodulatory and anti-inflammatory properties. However, the pharmacological effects of polysaccharides derived from Pistacia lentiscus L. leaves on inflammation-related gastric injury remain insufficiently characterized. AIM OF THE STUDY: This study evaluated the anti-inflammatory, antioxidant, and gastroprotective effects of crude sulfated polysaccharides from P. lentiscus leaves (CPL), with emphasis on their modulation of inflammatory and oxidative stress pathways. MATERIALS AND
methodsCPL was obtained by hot-water extraction followed by ethanol precipitation, yielding a crude water-soluble polysaccharide fraction without chemical modification. Structural features were preliminarily assessed using UV-visible and FTIR spectroscopy. Antioxidant activity was determined using DPPH radical scavenging, total antioxidant capacity, and reducing power assays. Anti-inflammatory activity was investigated via cyclooxygenase inhibition assays (COX-1 and COX-2). In vivo gastroprotective effects were evaluated in an ethanol-induced gastric injury model in mice, with analysis of oxidative stress and inflammation-related biomarkers, including superoxide dismutase (SOD), glutathione (GSH), and myeloperoxidase (MPO), alongside histopathological assessment.
resultsCPL exhibited strong antioxidant activity (DPPH IC
conclusionCrude sulfated polysaccharides from P. lentiscus leaves exhibited antioxidant activity, preferential inhibition of COX-2 over COX-1 in vitro, and protective effects against ethanol-induced gastric injury. CPL treatment restored antioxidant defenses, reduced MPO activity, and preserved gastric mucosal architecture, suggesting a role in the attenuation of oxidative stress and inflammatory tissue damage. These findings support the potential of P. lentiscus polysaccharides as bioactive agents for gastric protection. Further studies are required to elucidate the underlying molecular mechanisms and structure-activity relationships.
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