Evidence map›Paper›PMID 42365189›Full record

ArticleHepatology international2026

APASL clinical practice guidelines on the management of chronic hepatitis B infection: a 2026 update.

Hong You, Rakhi Maiwall, Jing Chen, Sang Hoon Ahn, Kadir Dokmeci, Xiaoguang Dou, Manal El-Sayed, Jian-Gao Fan, Rino Gani, Zhiliang Gao and 39 more

Abstract readEditorial
PubMed Publisher
In one paragraph

Article in Hepatology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. [Interpretation of key updates of the 2026 version of the APASL clinical practice guidelines for the management of chronic hepatitis B].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Guideline
  2. [Medical treatment of portal hypertensive bleeding in cirrhosis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Review
  3. [APASL clinical practice guidelines on the management of chronic hepatitis B infection: a 2026 update].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

49 authors.

Hong You *Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Rakhi Maiwall *Institute of Liver and Biliary Sciences, New Delhi, India.
Jing Chen *JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Sang Hoon AhnInstitute of Gastroenterology, Yonsei University College of Medicine, Seoul, South Korea.
Kadir DokmeciLiver Transplantation Center, Bahçeşehir University, Istanbul, Turkey.
Xiaoguang DouDepartment of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang, China.
Manal El-SayedDepartment of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Jian-Gao FanCenter for Fatty Liver, Department of Gastroenterology, Shanghai Key Lab of Pediatric Gastroenterology and Nutrition, Xin Hua Hospital, Shanghai Jiao Tong University, Shanghai, China.
Rino GaniFaculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Zhiliang GaoHepatic Hospital, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Jacob GeorgeStorr Liver Centre, The Westmead Millennium Institute for Medical Research, Westmead Hospital, The University of Sydney, Sydney, Australia.
Hasmik GhazinianYerevan Medical Scientific Center, Yerevan, Armenia.
George GohDepartment of Gastroenterology & Hepatology, Singapore General Hospital, Singapore, Singapore.
Saeed HamidAga Khan University, Karachi-74800, Pakistan.
Jinlin HouDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Shang-Chin HuangHepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan.
Dong JiSenior Department of Hepatology, Fifth Medical Center of Chinese, PLA General Hospital, Beijing, China.
Jidong JiaBeijing Friendship Hospital, Capital Medical University, Beijing, China.
Tatsuo KandaDivision of Gastroenterology and Hepatology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Minamiuonuma, 949-7302, Japan.
Jia-Horng KaoNational Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
Yoon Jun KimDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, 03080, South Korea.
Cosmas Rinaldi A LesmanaDepartment of Gastroenterology & Hepatology, Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, Jakarta, Indonesia.
Rosmawati MohamedDepartment of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Qin NingDepartment and Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Necati OrmeciIstanbul Health and Technology University, Istanbul, Turkey.
Motoyuki OtsukaDepartment of Gastroenterology and Hepatology, Okayama University, Okayama, Japan.
Diana PayawalDepartment of Medicine, Cardinal Santos Medical Center, Mandaluyong, Philippines.
Pham Thanh ThuyPartnership for Health Advancement in Vietnam, Hanoi, Vietnam.
Keo SaileyCommunicable Disease Control Department & Secretariat of Viral Hepatitis, Ministry of Health, Phnom Penh, Cambodia.
Manoj Kumar SharmaInstitute of Liver and Biliary Sciences, New Delhi, India.
Jose D SollanoFaculty of Medicine and Surgery, University of Santo Tomas, Manila, Philippines.
Jian SunDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Tawesak TanwandeeDivision of Gastroenterology, Faculty of Medicine Siriraj Hospital, Mahidol University, Salaya, Thailand.
Alexander ThompsonSt. Vincent's Hospital Melbourne, University of Melbourne, Melbourne, Australia.
Fu-Sheng WangTreatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, Beijing, 100039, China.
Guiqiang WangDepartment of Infectious Disease, Center for Liver Disease, Peking University First Hospital, Beijing, China.
Lai WeiSchool of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.
Grace Lai Hung WongMedical Data Analytics Centre, Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.
Vincent Wai Sun WongMedical Data Analytics Centre, Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.
Eng Kiong YeohJC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Terry Cheuk-Fung YipMedical Data Analytics Centre, Department of Medicine & Therapeutics, Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Ming-Lung YuHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Wenhong ZhangShanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, China.
Hui ZhuangDepartment of Microbiology and Centre for Infectious Diseases, Peking University Health Science Centre, Beijing, China.
Ching-Lung LaiThe University of Hong Kong, Hong Kong SAR, China.
Masao OmataYamanashi Hospitals (Central and Kita) Organization, 1-1-1 Fujimi, Kofu-Shi, Yamanashi, 400-8506, Japan.
Shiv Kumar SarinInstitute of Liver and Biliary Sciences, New Delhi, India.
George LauHumanity and Health Clinical Trial Center, Hong Kong SAR, China. gkklau@netvigator.com.ORCID http://orcid.org/0000-0002-8928-3769
APASL Viral Elimination Taskforce

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Globally, especially in the Asia Pacific region, chronic hepatitis B infection has led to an undesirable escalating morbidity and mortality with acute-on chronic liver failure, end-staged liver cirrhosis, and hepatocellular carcinoma. This has happened despite the past four decades of major scientific advances made in screening methods, vaccination strategies, highly effective low-cost anti-viral therapies, and surveillance strategies for early detection of hepatocellular carcinoma. To address this health threat, APASL has formed a Viral Elimination Taskforce to unite key opinion leaders from its member countries and regions. The ongoing shifts in hepatitis B epidemiology, socioeconomic changes, and advancements in technology are taken into consideration. With the conjoint efforts of all the members of the APASL Viral Elimination Taskforce, these clinical practice guidelines have been formulated aiming to facilitate healthcare professionals, policy-makers, and patients in making practical and cost-effective management decisions for chronic hepatitis B infection. Altogether, it provides recommendations in 13 major areas related to screening, vaccination, treatment, and HCC surveillance. The implementation of these clinical practice guidelines represents major APASL effort toward elimination of the disease burden due to chronic hepatitis B infection in Asia Pacific region.

Indexed as

Chronic hepatitis BGuidelineHepatocellular carcinomaPreventionTreat allTreatment

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.