ArticleBritish journal of cancer2026
Ovarian cancer tumor immune profiles associated with intrauterine device and oral contraceptive use.
Article in British journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundNon-hormonal intrauterine devices (IUDs) create an inflammatory uterine environment while oral contraceptives (OC) suppress ovulation and have different associations with ovarian cancer risk. We have evaluated the associations of these two contraceptive exposures with ovarian tumor immune infiltration.
methodsThis study assessed associations of IUD and OC use with tumor immune features via multiplex immunofluorescence in 24 ovarian tumor tissue microarrays from four case-control and two cohort studies. Multivariable-adjusted beta-binomial models estimated the odds of tumor T cell positivity by contraceptive history.
resultsHigh-grade serous tumors had the highest percentage of tumor cells positive for total T cells (CD3
conclusionsPre-diagnostic contraception use may influence ovarian tumor immunity and may modulate cancer susceptibility.
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