Evidence map›Paper›PMID 42364979›Full record

SynthesisNature communications2026

Development and validation of a multiancestry and multitrait polygenic risk score for lung cancer.

Yixin Zhang, Jinglan Dai, Pan Gu, Yang Zhao, David C Christiani, Feng Chen, Sipeng Shen

Abstract readValidation StudyMeta-Analysis
In one paragraph

Synthesis in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yixin Zhang *Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Jinglan Dai *Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Pan Gu *Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Yang ZhaoDepartment of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
David C ChristianiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0301-0242
Feng ChenDepartment of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. fengchen@njmu.edu.cn.
Sipeng ShenDepartment of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. sshen@njmu.edu.cn.ORCID http://orcid.org/0000-0003-0436-4736

Funding

The Boston Lung Cancer Survival CohortU01CA209414 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI David C Christiani · 2017 to 2026
$12.2M
National Natural Science Foundation of China (National Science Foundation of China) 82220108002National Natural Science Foundation of China (National Science Foundation of China) 82373685NCI NIH HHS U01 CA209414U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) U01CA209414
6 · The paper itself

Abstract

Polygenic risk scores (PRSs) quantify genetic susceptibilities, yet ancestry imbalance in genome-wide association studies (GWASs) limits the accuracy of monoracial PRSs in non-European populations. Here, we perform a multiancestry GWAS meta-analysis for lung cancer (76,953 cases and 1,886,372 controls), identifying 87 conditionally independent genome-wide significant loci, including two unreported cytobands. We use a PRS construction method, PRS-CSx, to develop a multiancestry PRS (

Indexed as

Genetic Predisposition to DiseaseGenetic Risk ScoreLung NeoplasmsAsian PeopleBlack PeopleGenome-Wide Association StudyHumansPolymorphism, Single NucleotideWhite People

Identifiers

PMID42364979
PMCPMC13454572

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.