ArticleContemporary clinical trials2026
Are older adult research participants representative of the general population? Results from 19 clinical studies at one academic research center.
Rebecca H Neiberg, Xiaoyan Leng, Denise K Houston, Kristen M Beavers, Michael E Miller, Kimberly Kennedy, Jason Fanning, Megan B Irby, Dalane W Kitzman, Stephen B Kritchevsky and 1 more
Abstract read
In one paragraphArticle in Contemporary clinical trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Rebecca H NeibergWake Forest University School of Medicine, United States of America. Electronic address: Rebecca.Neiberg@AdvocateHealth.org.
Xiaoyan LengWake Forest University School of Medicine, United States of America.
Denise K HoustonWake Forest University School of Medicine, United States of America.
Kristen M BeaversWake Forest University School of Medicine, United States of America.
Michael E MillerWake Forest University School of Medicine, United States of America.
Kimberly KennedyWake Forest University School of Medicine, United States of America.
Jason FanningWake Forest University, United States of America.
Megan B IrbyWake Forest University, United States of America.
Dalane W KitzmanWake Forest University School of Medicine, United States of America.
Stephen B KritchevskyWake Forest University School of Medicine, United States of America.
Barbara J NicklasWake Forest University School of Medicine, United States of America.
Funding
Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LEON LENCHIK · 2002 to 2026
$36.4MWORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WASHBURN, LISA K · 1992 to 2010
$35.2MPepper OAIC Coordinating CenterU24AG059624 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DALANE W KITZMAN · 2018 to 2026
$6.0MExercise Intolerance in Older HFPEF PatientsR01AG018915 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2001 to 2019
$5.2MThe Mobile Devices for Meal Timing (MD4MT) Study: A supplement to HALLO-P using multiple wearable devise to improve accuracy in meal timing for older adults2U01AG073240 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KRITCHEVSKY, STEPHEN B., MILLER, MICHAEL E. · 2021 to 2024
$4.4MCombining assessment of cognition, eye movement, and gait in naturalistic settings to differentiate subclinical Alzheimer's pathology.R01AG052419 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KRITCHEVSKY, STEPHEN B., LAURIENTI, PAUL · 2017 to 2022
$4.2MLoss of fat tissue and functional responses to exercise in older, obese adultsR01AG020583 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI NICKLAS, BARBARA J · 2002 to 2013
$4.0MIntervening on sedentary behavior to prevent weight regain in older adultsR01AG051624 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI NICKLAS, BARBARA J, REJESKI, WALTER JOHN · 2016 to 2020
$3.8MTrial of vitamin D supplementation and neuromuscular functioin in older adultsR01AG042411 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HOUSTON, DENISE KATHRYN · 2013 to 2017
$3.4MEffect of fat loss on functional and cardiovascular benefits of aerobic exerciseR01HL093713 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI NICKLAS, BARBARA J · 2009 to 2013
$3.4MVascular Stiffness and Pulmonary CongestionR01HL076438 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUNDLEY, WILLIAM GREGORY · 2007 to 2011
$3.2MEXERCISE AND DISABILITY IN COPD PATIENTSR01HL053755 · NHLBI · WAKE FOREST UNIVERSITY · PI BERRY, MICHAEL J · 1995 to 2005
$3.1MNCRR NIH HHS M01 RR007122NHLBI NIH HHS R01 HL053755NHLBI NIH HHS R01 HL068901NHLBI NIH HHS R01 HL076438NHLBI NIH HHS R01 HL076441NHLBI NIH HHS R01 HL093713NIAMS NIH HHS R01 AR052528NIA NIH HHS K01 AG047921NIA NIH HHS P30 AG021332NIA NIH HHS R01 AG018915NIA NIH HHS R01 AG020583NIA NIH HHS R01 AG042411NIA NIH HHS R01 AG050656NIA NIH HHS R01 AG051624NIA NIH HHS R01 AG052419NIA NIH HHS R01 AG059186NIA NIH HHS U01 AG073240NIA NIH HHS U24 AG059624
6 · The paper itselfAbstract
backgroundTo implement strategies for enhancing research participation across a broad range of personal characteristics, additional data are needed regarding the degree of underrepresentation of specific individuals in research.
methodsThis study analyzed data from 3671 older (mean age 69 yrs) individuals enrolled in 19 studies conducted from 2002 to 2023 at Wake Forest University School of Medicine. Study inclusion was limited to those with a minimum age eligibility of 50 years. Demographic data of enrolled participants were compared to 1) individuals phone screened for participation and 2) US Census data of older individuals residing in the zip codes of the catchment area.
resultsThere were 11 studies with screening data available, and the overall enrollment yield was 11.1% (n = 2207 of n = 19,895 screened). Those enrolled were similar in age to those who screened out, and a greater proportion of males (14.5%) versus females (12.4%) and White (22.3%) versus Black participants (19.4%) were enrolled after screening. Compared to Census estimates of older adults, individuals that were 75+ years at enrollment were underrepresented (Census 29%, enrolled 18%; PPR = 0.6), older adults with at least some college education were overrepresented (Census 24%, enrolled 80%; PPR = 3.27) and individuals who specified Black or African American ethnicity were slightly overrepresented (Census 14%, enrolled 19%; PPR = 1.31). Older adults who were 65 years or older, female, or had White ethnicity had proportional representation at enrollment.
conclusionsThe research participants included across these studies had underrepresentation of adults older than 75 years and overrepresentation of college-educated and Black or African American race.
Indexed as
Biomedical ResearchPatient SelectionResearch SubjectsAgedAged, 80 and overBlack or African AmericanFemaleHumansMaleMiddle AgedWhiteDemographicsRecruitmentResearch participant
Identifiers
PMID42364729
PMCPMC13563415
What OpenQuestion holds
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