ArticleActa orthopaedica et traumatologica turcica2026
Comparison of the effects of injectable platelet-rich fibrin and concentrated growth factor on tendon-bone interface healing in the rabbit rotator cuff tear model.
Article in Acta orthopaedica et traumatologica turcica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to evaluate and compare the effects of injectable platelet-rich fibrin (I-PRF) and concentrated growth factor (CGF) on tendon-to-bone interface healing in a rabbit model of rotator cuff tear.
methodsA full-thickness supraspinatus tendon tear was surgically induced in both shoulders of 18 adult New Zealand White rabbits. The animals were randomly assigned into 3 groups: Group 1 received CGF, Group 2 received I-PRF, and Group 3 served as the control group with no biological augmentation. In Groups 1 and 2, CGF and I-PRF were applied to the repair site of the rotator cuff tendon following surgical reattachment. Six weeks postoperatively, all rabbits were sacrificed. The supraspinatus tendon along with the humeral head was harvested. Histological analysis was performed on specimens from the left shoulders, while biomechanical testing was conducted on those from the right shoulders. Biomechanical evaluation included measurements of failure load and elongation. Histological and immunohistochemical assessments were carried out using the Nourissat tendon-bone interface scoring system.
resultsBiomechanical testing demonstrated that the CGF group exhibited significantly greater failure load compared to the other groups P = .001. Mean elongation values were 3.9 mm in the CGF group, 3.1 mm in the I-PRF group, and 2.5 mm in the control group, with a statistically significant difference favoring CGF P = .03. Although no significant differences were observed among the groups regarding cell density at the tendon-bone interface P = .237 or chondrocyte organization P = .327, the CGF group showed significantly higher scores for type 2 collagen content P = .0001, glycosaminoglycan content P = 0.001, and collagen fiber organization P = .004.
conclusionThe application of CGF significantly enhanced tendon-to-bone healing in a rabbit rotator cuff repair model when compared to I-PRF, as evidenced by superior biomechanical and histological outcomes. Cite this article as: Sözgen E, Önal MS, Yörükoğlu A.. Comparison of the effects of injectable platelet-rich fibrin (I-PRF) and concentrated growth factor (CGF) on tendon-bone interface healing in the rabbit rotator cuff tear model. Acta Orthop Traumatol Turc., 2026; 60(2), 0431, doi: 10.5152/j.aott.2026.25431.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.