Evidence map›Paper›PMID 42364058›Full record

ArticleScience China. Life sciences2026

Dynamic tRNA modification landscapes reveal METTL1 in fibroblasts as a central regulator of aging.

Yan Zhu, Xin Wang, Yun Li, Wenlin Jiang, Zheng Wu, San Xu, Zixin Tan, Aike Wu, Yisheng Cai, Yandi Yang and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yan Zhu *Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Xin Wang *Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Yun Li *Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Wenlin Jiang *Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Zheng WuDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China.
San XuDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Zixin TanDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Aike WuDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Yisheng CaiDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Yandi YangDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Xin XiaoDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Xinwei KuangDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Guangtong DengDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Yiya ZhangDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Mengting ChenDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China. cmt0702@csu.edu.cn.
Ji LiDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China. liji_xy@csu.edu.cn.
Yunfang ZhangClinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. zhangyunfang@tongji.edu.cn.
Zhili DengDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China. dengzhili@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA modifications have emerged as crucial regulators of cellular processes linked to aging. However, the dynamic changes in global RNA modification patterns during aging and their functional implications remain underexplored. Here, we comprehensively deciphered the RNA modification landscapes of total RNA, poly(A)-enriched mRNA, and tRNA-enriched fragments across six tissues in both young and aged mice, as well as in multiple cellular senescence models. Aged tissues exhibit overall decline of RNA modification abundance in tRNA, rather than in total RNA or mRNA, when compared to young tissues. Correspondingly, the expression of tRNA methyltransferases, METTL1 and TRMT1, also declines with aging and senescence. Modulation of these methyltransferases affects cellular senescence phenotypes; specifically, Mettl1 depletion results in accelerated aging in mice. Mechanistically, fibroblasts are identified as the primary cell type responsible for the aging traits induced by Mettl1 deficiency in mice. Reduced m

Indexed as

agingfibroblastsm7GMETTL1RNA modificationssenescencetRNA

Identifiers

PMID42364058

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.