ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Impact of weight loss on adverse events during chemoradiotherapy in patients with small cell lung cancer: a retrospective study.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeRadiation oesophagitis, a common adverse event of radiation therapy for limited-disease small cell lung cancer (LD-SCLC), results in significant weight loss. This study retrospectively evaluated the association between weight loss and treatment outcomes in patients with LD-SCLC undergoing chemoradiotherapy and explored the associated factors.
methodsPatients with LD-SCLC treated with concurrent chemoradiotherapy between 2010 and 2023 were included. We compared the characteristics of patients with and without radiation oesophagitis or ≥ 5% weight loss during treatment.
resultsOf 99 patients included, radiation oesophagitis occurred in 71. The incidence of febrile neutropenia (FN) was significantly higher in the grade 2-3 oesophagitis group than in the grade 0-1 group (72.7% vs. 45.5%; P = 0.030). In patients with FN, creatinine clearance significantly decreased after treatment (84.2 ± 21.4 mL/min to 76.5 ± 20.4 mL/min; P < 0.001). Twenty-five patients (25.3%) had ≥ 5% weight loss by the end of radiotherapy. Patients with ≥ 5% weight loss had a significantly higher incidence of FN than those with < 5% weight loss (80.0% vs. 43.2%; P = 0.002). On multivariate logistic regression analysis, FN was significantly associated with weight loss ≥ 5% (OR 4.49, 95% CI 1.47-13.80; P = 0.009).
conclusionThis study suggests that weight loss of ≥ 5% during chemoradiotherapy is associated with an increased incidence of FN among patients with LD-SCLC. These preliminary findings suggest that the clinical utility of close monitoring and early supportive care for patients at risk of weight loss warrants further prospective investigation.
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