Evidence map›Paper›PMID 42364030›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2026

Rice-Derived Peptides Exhibit Wound Healing Properties in Human Keratinocytes: Screening, Identification, and Mechanism Revelation.

Tingmin Qu, Shiyu Wen, Liangjie Hu, Ying Wu, Ruibo Huang, Hao Wu, Daichen Mu, Qingming Huang, Jian Hu, Li Wen

Abstract read
PubMed Publisher
In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tingmin QuSchool of Food Science and Bioengineering, Hunan Provincial Key Laboratory of Cytochemistry, Changsha University of Science & Technology, Changsha, 410114, P.R. China.
Shiyu WenSchool of Food Science and Bioengineering, Hunan Provincial Key Laboratory of Cytochemistry, Changsha University of Science & Technology, Changsha, 410114, P.R. China.
Liangjie HuSchool of Food Science and Bioengineering, Hunan Provincial Key Laboratory of Cytochemistry, Changsha University of Science & Technology, Changsha, 410114, P.R. China.
Ying WuSchool of Food Science and Bioengineering, Hunan Provincial Key Laboratory of Cytochemistry, Changsha University of Science & Technology, Changsha, 410114, P.R. China.
Ruibo HuangSchool of Food Science and Bioengineering, Hunan Provincial Key Laboratory of Cytochemistry, Changsha University of Science & Technology, Changsha, 410114, P.R. China.
Hao WuSchool of Food Science and Bioengineering, Hunan Provincial Key Laboratory of Cytochemistry, Changsha University of Science & Technology, Changsha, 410114, P.R. China.
Daichen MuSchool of Food Science and Bioengineering, Hunan Provincial Key Laboratory of Cytochemistry, Changsha University of Science & Technology, Changsha, 410114, P.R. China.
Qingming HuangHunan Zhunong Rice Industry Co., Ltd, Yiyang, 413200, P.R. China.
Jian HuHunan Zhunong Rice Industry Co., Ltd, Yiyang, 413200, P.R. China.
Li WenSchool of Food Science and Bioengineering, Hunan Provincial Key Laboratory of Cytochemistry, Changsha University of Science & Technology, Changsha, 410114, P.R. China. wl@csust.edu.cn.ORCID http://orcid.org/0000-0002-8671-2046

Funding

National Natural Science Foundation of China 31972077Postgraduate Scientific Research Innovation Project of Hunan Province CX20240814Science and Technology Innovation Program of Yiyang City in Hunan Province 2024YY19
6 · The paper itself

Abstract

Food-derived biopeptides have attracted increasing attention due to their potential health benefits and favorable safety profiles. In this study, rice protein hydrolysates (< 3 kDa) and their derived peptides were investigated for their protective effects against tumor necrosis factor (TNF)-α/interferon (IFN)-γ-induced injury in human keratinocyte cells (HaCaT). The hydrolysates significantly enhanced cell viability and migration, and five peptides were identified by LC-MS/MS and in-silico analysis. These peptides improved the viability of damaged cells, with PG9 (PSWVAFTGG) showing the greatest activity. PG9 significantly downregulated the mRNA expression of pro-inflammatory cytokines, including Regulated on Activation, Normal T-cell Expressed and Secreted (RANTES), Interleukin (IL)-1β, IL-6, and IL-23, while also markedly promoting keratinocyte migration. Molecular dynamics simulations revealed that PG9 formed stable hydrogen-bonds with key residues (Lys745 and Asp855) within the epidermal growth factor receptor (EGFR) binding site, suggesting its involvement in EGFR-mediated wound healing signaling. In addition, PG9 regulated the PI3K/AKT/mTOR pathway by reducing the expression of PI3K, AKT, mTOR, and inhibiting AKT phosphorylation. These results identify PG9 as a stable EGFR-binding peptide capable of modulating inflammatory signaling and supporting its potential as a natural agent for skin repair.

Indexed as

KeratinocytesOryzaPeptidesWound HealingBioactive Peptides, DietaryCell MovementCell SurvivalCytokinesErbB ReceptorsHaCaT CellsHumansInterferon-gammaPhosphatidylinositol 3-KinasesProtein HydrolysatesProto-Oncogene Proteins c-aktSignal TransductionBioactive Peptides, DietaryCytokinesErbB ReceptorsInterferon-gammaPeptidesPhosphatidylinositol 3-KinasesProtein HydrolysatesProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesTumor Necrosis Factor-alphaAnti-inflammationEGFRPeptidePI3K/AKT/mTORRice proteinWound healing

Identifiers

PMID42364030

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.