ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Visual and refractive outcomes of retinopathy of prematurity in school-age patients.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate visual and refractive outcomes in school-aged patients with a history of prematurity and retinopathy of prematurity (ROP) with or without treatment.
methodsThis is a retrospective cross-sectional study. Participants were categorized into five groups: full-term, preterm without ROP, ROP without treatment, intravitreal injection of anti-vascular endothelial growth factor (IVI)-treated ROP, and laser indirect ophthalmoscopy (LIO)-treated ROP. Patients underwent comprehensive ophthalmic examinations, including cycloplegic refraction and optical biometry. Comparisons were stratified into two age cohorts: 5 ≤ AGE < 10 and 10 ≤ AGE ≤ 13. Refractive errors, axial length (AL), anterior chamber depth (ACD), corneal parameters, and lens thickness were measured and compared between the groups.
resultsA total of 310 patients were enrolled in the study. Significant intergroup differences in AL, ACD, white-to-white distance, and best-corrected visual acuity (BCVA) were observed across both age cohorts (all p < 0.05). In the older age cohort, post-hoc analysis revealed that LIO-treated eyes had significantly shorter AL (22.73 ± 1.51 mm vs. 24.39 ± 0.89 mm, p = 0.0057), shallower ACD (3.31 ± 0.46 mm vs. 3.78 ± 0.22 mm), smaller corneal diameter (11.53 ± 0.35 mm vs. 12.29 ± 0.42 mm, p = 0.0018), and steeper corneal curvature (46.23 ± 1.53 D vs. 42.95 ± 1.37 D, p = 0.0002) compared with full-term controls. When directly compared with IVI-treated eyes in the older cohort, LIO-treated eyes had significantly thinner corneas (p = 0.04) and steeper corneal curvature (p = 0.005). IVI-treated eyes exhibited biometric and refractive profiles similar to those of untreated ROP.
conclusionROP and its treatment have long-term effects on ocular development and refraction. Laser-treated patients exhibited significantly higher myopia and astigmatism, shorter axial length, shallower anterior chambers, and smaller corneal diameters, particularly in older age groups. In contrast, IVI-treated eyes had a biometry closer to that of untreated ROP.
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