Evidence map›Paper›PMID 42363980›Full record

ArticleArchives of toxicology2026

Species, cell proliferation state and oxygen partial pressure are major factors in the in vitro toxicity of repurposed potential ADPKD drugs in human and murine renal proximal tubule cells.

Paraskevi Sotiropoulou, Andrea Gerdemann, Stefan Jovanovic, Hans-Ulrich Humpf, Alexander Bürkle, Daniel R Dietrich

Abstract read
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In one paragraph

Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paraskevi SotiropoulouHuman and Environmental Toxicology, University of Konstanz, Konstanz, Germany. Paraskevi.Sotiropoulou@uni-konstanz.de.
Andrea GerdemannInstitute of Food Chemistry, University of Münster, Münster, Germany.
Stefan JovanovicMolecular Toxicology, University of Konstanz, Konstanz, Germany.
Hans-Ulrich HumpfInstitute of Food Chemistry, University of Münster, Münster, Germany.
Alexander BürkleMolecular Toxicology, University of Konstanz, Konstanz, Germany.
Daniel R DietrichHuman and Environmental Toxicology, University of Konstanz, Konstanz, Germany. Daniel.Dietrich@uni-konstanz.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unexpected nephrotoxicity during clinical stages of drug development, due to undetected toxicity in in vitro and in vivo settings, can lead to drug attrition and jeopardize drug development. The latter highlights the importance of in vitro renal toxicity testing that can safely be translated to humans. Two factors commonly overlooked in the latter are the continuous cell proliferation that occurs in regeneration processes after renal insult and the physiological O

Indexed as

Cell proliferationDrug repurposingOxidative stressPhysiological oxygenPolycystic kidney diseaseRenal proximal tubular cell toxicity

Identifiers

PMID42363980

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.