ArticleJournal of applied physiology (Bethesda, Md. : 1985)2026
Characterization of intracranial pressure variations in ventricular and subarachnoid spaces of the rat brain.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Intracranial pressure (ICP) is a dynamic physiological signal shaped by cerebrospinal fluid (CSF) flow, vascular pulsations, and brain tissue compliance, yet most knowledge of CSF (cerebrospinal fluid) hydrodynamics comes from pathological states in humans. To better understand physiological ICP variability, dual recordings were obtained in 15 healthy anesthetized Brown-Norway rats using pressure sensors connected to cannulas in the lateral ventricle (vICP) and subarachnoid space (sICP). Spectral analysis quantified cardiac and respiratory oscillations, whereas slower waves were detected by thresholding, characterized with principal component analysis, and modeled to estimate amplitude and duration. In five animals, intracranial hypertension was induced via ventricular fluid infusion. Mean pressures differed slightly, but not significantly, between compartments (vICP 6.05 ± 0.90 mmHg vs. sICP 5.90 ± 0.90 mmHg;
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