Evidence map›Paper›PMID 42363832›Full record

ArticleAntimicrobial agents and chemotherapy2026

Inhibition of PfCLK3 interferes with malaria parasite RNA splicing and explains the mechanism of action of a new class of antimalarial candidates.

Omar Janha, Niniola Olaniyan, Go Ka Diam, Saumya Sharma, Dario Beraldi, Andrew G Jamieson, Zbynek Bozdech, Andrew B Tobin, Katarzyna Modrzynska

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Omar JanhaKeltic Pharma Therapeutics Limited, Advanced Research Centre, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0002-9121-2396
Niniola OlaniyanSchool of Molecular Biosciences, Advanced Research Centre, University of Glasgow, Glasgow, United Kingdom.
Go Ka DiamSchool of Biological Sciences, Nanyang Technological University, Singapore, Singapore.ORCID 0000-0003-1782-2775
Saumya SharmaKeltic Pharma Therapeutics Limited, Advanced Research Centre, University of Glasgow, Glasgow, United Kingdom.
Dario BeraldiSchool of infection and Immunity, College of Medical, Veterinary and Life Science, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0003-1504-5212
Andrew G JamiesonSchool of Chemistry Advanced Research Centre, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0003-1726-7353
Zbynek BozdechSchool of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Andrew B TobinSchool of Molecular Biosciences, Advanced Research Centre, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0002-1807-3123
Katarzyna ModrzynskaSchool of infection and Immunity, College of Medical, Veterinary and Life Science, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0002-0877-3564

Funding

Bill & Melinda Gates Foundation INV-039928Gates Family Foundation INV-088781Gates Foundation INV-039928Ministry of Education, Singapore MOE2019-T3-1-007Royal Society 202600/Z/16/ZWellcome TrustWellcome Trust 202600/Z/16/Z
6 · The paper itself

Abstract

Emerging resistance to front-line antimalarials means there is an urgent need to discover new drugs with novel mechanisms of action that remain effective across multiple stages of the parasite life cycle. Previously, we reported a malaria parasite protein kinase,

Indexed as

AntimalarialsPlasmodium falciparumProtein Kinase InhibitorsProtein Serine-Threonine KinasesProtozoan ProteinsRNA SplicingHumansProtein-Tyrosine KinasesSpliceosomesAntimalarialsClk dual-specificity kinasesProtein Kinase InhibitorsProtein Serine-Threonine KinasesProtein-Tyrosine KinasesProtozoan Proteinsdrug discoverymalariamechanisms of actionmitogen-activated protein kinasesPfCLK3protein kinasessplicingtarget validationTCMDC-135051

Identifiers

PMID42363832
PMCPMC13435738

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.