Observational studyPain research & management2026
Characteristics of Pain in Patients Diagnosed With Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders. An Observational Study.
Observational study in Pain research & management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04133272 (Registry of Ehlers-Danlos Syndrome That Collects Clinical, Functional, Genetic, Genealogical, Imaging, Surgical, Treatment, Quality of Life Data. Data Are Linked to Patients' Biological Samples, When Available), which is not on this map. Cited by 1 paper.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Registry of Ehlers-Danlos Syndrome That Collects Clinical, Functional, Genetic, Genealogical, Imaging, Surgical, Treatment, Quality of Life Data. Data Are Linked to Patients' Biological Samples, When Available
Who cites it
1 citing paper in PubMed.
- Characteristics of Pain in Patients Diagnosed With Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders. An Observational Study.Pain research & management · 2026Observational
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundThis study aimed to describe pain characteristics in patients diagnosed with Ehlers-Danlos syndrome (EDS) or hypermobility spectrum disorders (HSD) and to identify factors associated with moderate to severe pain at diagnosis.
methodsNinety-six patients were retrospectively identified through the Ce.Ma.R.S. registry (2017-2022). Pain intensity was assessed at first evaluation using a Numeric Rating Scale (0-10). Patients were grouped into no/mild pain and moderate/severe pain. Clinical and demographic data were collected, and variables significant in univariate analysis were included in multivariate logistic regression.
resultsAt diagnosis, 49% of patients reported moderate to severe pain. Independent predictors were older age (OR = 1.06; 95% CI: 1.03-1.10), diagnosis of hypermobile EDS (OR = 6.25; 95% CI: 1.31-29.74), and headache (OR = 3.97; 95% CI: 1.14-13.82). Use of pain medications, particularly paracetamol and NSAIDs, was strongly associated with higher pain severity (p < 0.001).
conclusionPain is a common and early symptom in EDS and HSD. Older patients, those with hypermobile EDS, and those with headache are at greater risk of severe pain. Early, multidisciplinary pain management, including pharmacological treatment, physiotherapy, and headache-specific strategies, should be prioritized to improve outcomes and reduce long-term disability.
trial registrationClinicalTrials.gov identifier: NCT04133272.
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