Evidence map›Paper›PMID 42363778›Full record

ArticlePest management science2026

Design, synthesis and antifungal evaluation of novel indoline-containing pyrazole-4-carboxamide derivatives as potential succinate dehydrogenase inhibitors.

Bo Luo, Yanbing Wu, Lu Yu, Ruxin Han, Wenjing Niu, Zhanghan Gao, Huanxi Cui, Xiaoyang Zhao, Dan Li, Xiaoyu Feng and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bo LuoHenan Key Laboratory of Tea Plant Biology, Xinyang Key Laboratory of Food Innovation for Tea and Camellia oleifera, College of Tea and Food Science, Xinyang Normal University, Xinyang, China.ORCID https://orcid.org/0000-0001-8519-4446
Yanbing WuHenan Key Laboratory of Tea Plant Biology, Xinyang Key Laboratory of Food Innovation for Tea and Camellia oleifera, College of Tea and Food Science, Xinyang Normal University, Xinyang, China.
Lu YuCollege of Life Sciences, Xinyang Normal University, Xinyang, China.
Ruxin HanCollege of Life Sciences, Xinyang Normal University, Xinyang, China.
Wenjing NiuCollege of Life Sciences, Xinyang Normal University, Xinyang, China.
Zhanghan GaoCollege of Life Sciences, Xinyang Normal University, Xinyang, China.
Huanxi CuiCollege of Life Sciences, Xinyang Normal University, Xinyang, China.
Xiaoyang ZhaoCollege of Life Sciences, Xinyang Normal University, Xinyang, China.
Dan LiCollege of Life Sciences, Xinyang Normal University, Xinyang, China.
Xiaoyu FengCollege of Life Sciences, Xinyang Normal University, Xinyang, China.
Yuting HanHenan Key Laboratory of Tea Plant Biology, Xinyang Key Laboratory of Food Innovation for Tea and Camellia oleifera, College of Tea and Food Science, Xinyang Normal University, Xinyang, China.
Qiuqin LiHenan Key Laboratory of Tea Plant Biology, Xinyang Key Laboratory of Food Innovation for Tea and Camellia oleifera, College of Tea and Food Science, Xinyang Normal University, Xinyang, China.
Yihan HuHenan Key Laboratory of Tea Plant Biology, Xinyang Key Laboratory of Food Innovation for Tea and Camellia oleifera, College of Tea and Food Science, Xinyang Normal University, Xinyang, China.
Lailiang QuCollege of Medicine, Xinyang Normal University, Xinyang, China.

Funding

National Natural Science Foundation of ChinaNatural Science Foundation of Henan ProvinceScientific and Technological Frontiers in Project of Henan Province
6 · The paper itself

Abstract

backgroundPlant diseases caused by various pathogenic fungi significantly reduce productivity and threaten food safety. Chemical fungicides remain a cornerstone in the management of fungal infections afflicting crops. In search for more potent succinate dehydrogenase inhibitors (SDHIs) for crop protection, a series of novel indoline-containing pyrazole-4-carboxamide derivatives were designed and synthesized.

resultsThe assay results indicated that the majority of compounds incorporating a benzyl group displayed remarkable antifungal efficacies. Notably, compound 6j emerged as a standout, exhibiting the highest potency against Rhizoctonia solani, with a half-maximal effective concentration (EC

conclusionThese findings indicated that compounds 6j and 6i could serve as promising SDHI candidates for crop protection, warranting further investigation. © 2026 Society of Chemical Industry.

Indexed as

Enzyme InhibitorsFungicides, IndustrialIndolesPyrazolesSuccinate DehydrogenaseAscomycotaDrug DesignPlant DiseasesRhizoctoniaEnzyme InhibitorsFungicides, IndustrialIndolesindolinePyrazolesSuccinate Dehydrogenaseantifungalindolinemechanismpyrazole‐4‐carboxamideSDHIs

Identifiers

PMID42363778
PMCPMC13569232

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.