Evidence map›Paper›PMID 42363726›Full record

Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Cardiovascular-kidney-metabolic syndrome stage modifies the efficacy of intensive blood pressure control on cognitive outcomes: A post hoc analysis of SPRINT MIND.

Zhongxiao Wang, Junyu Pei, Tienan Sun, Siqi Ge, Taoyang Wu, Yuzhe Yin, Haipeng Wang, Jialiang Yang, Keyang Zheng

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhongxiao WangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Junyu PeiDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Hunan, China.
Tienan SunDepartment of Cardiology, Capital Medical University Affiliated Anzhen Hospital, Beijing, China.
Siqi GeDepartment of Neuroepidemiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Taoyang WuSchool of Computing Sciences, University of East Anglia, Norwich, UK.
Yuzhe YinDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Haipeng WangDepartment of Neurology, Beijing Aerospace General Hospital, Beijing, China.
Jialiang YangAcademician Workstation, Changsha Medical University, Changsha, China.
Keyang ZhengDepartment of General Practice, Beijing Nuclear Industry Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWhether cardiovascular-kidney-metabolic (CKM) syndrome stage modifies cognitive benefits of intensive blood pressure (BP) control remains unclear.

methodsThis post hoc analysis of ‌Systolic Blood Pressure Intervention Trial - Memory and Cognition in Decreased Hypertension (SPRINT MIND) classified participants into non-advanced CKM (Stage 2, n = 5,632) and advanced CKM (Stages 3-4, n = 2,931). The primary outcome was probable dementia; secondary outcomes included mild cognitive impairment (MCI) and probable dementia or MCI composite. Treatment effects were evaluated using Cox models and generalized linear models.

resultsIn non-advanced CKM, intensive BP control reduced risks of probable dementia (hazard ratio [HR] 0.62, 95% confidence interval [CI] 0.46-0.85) and composite outcome (HR 0.74, 95% CI 0.62-0.89). No benefit was observed in advanced CKM (probable dementia: HR 1.15; composite: HR 0.97). Significant interactions between treatment and CKM stage were observed for probable dementia (p = 0.009).

conclusionAmong patients with hypertension and non-advanced CKM syndrome, intensive BP control was associated with lower risk of probable dementia, whereas no such benefit was observed in advanced CKM (see Graphical Abstract).

Indexed as

Antihypertensive AgentsCardio-Renal SyndromeCognitionCognitive DysfunctionDementiaHypertensionMetabolic SyndromeAgedBlood PressureFemaleHumansMaleAntihypertensive Agentscardiovascular–kidney–metabolic syndromecognitive functiondementiaintensive blood pressure controlmild cognitive impairmentSPRINT trial

Identifiers

PMID42363726
PMCPMC13309852

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.