Evidence map›Paper›PMID 42363705›Full record

ArticleAnnals of medicine2026

Association between maternal serum RANKL and adverse birth outcomes: a prospective cohort study.

Xiaoqiong Wu, Jiamei Wang, Aiqi Yin, Binbin Huang, Fa Zeng

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Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Xiaoqiong WuJiaxing Center for Disease Control and Prevention, Jiaxing, Zhejiang, China.
Jiamei WangDepartment of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, Anhui, China.
Aiqi YinDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Binbin HuangDepartment of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, Anhui, China.
Fa ZengShenzhen Longhua Maternity and Child Healthcare Hospital, Shenzhen, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdverse birth outcomes remain a global public health issue. RANKL participates in immune regulation and bone metabolism, but its association with adverse birth outcomes has not been fully clarified.

objectiveTo explore the association between maternal mid-pregnancy serum RANKL levels and adverse birth outcomes (PTB, BD, SGA, LGA, LBW, macrosomia).

methodsThis was a cross-sectional study conducted in South China. Maternal serum samples were collected during the second trimester (13-20 gestational weeks). Serum RANKL levels were measured, and logistic regression and restricted cubic spline analyses were used to evaluate the associations.

resultsMaternal mid-pregnancy serum RANKL levels were significantly positively associated with SGA. ROC analysis suggested that serum RANKL had a certain discriminatory ability for SGA and LBW.

conclusionMid-pregnancy maternal serum RANKL levels are associated with an increased risk of SGA. Serum RANKL may serve as a potential indicator for risk assessment of adverse birth outcomes. These findings provide new clues for understanding the aetiology of adverse birth outcomes.

Indexed as

Pregnancy OutcomeRANK LigandAdultBiomarkersBirth WeightChinaCross-Sectional StudiesFemaleFetal MacrosomiaHumansInfant, Large for Gestational AgeInfant, Low Birth WeightInfant, NewbornInfant, Small for Gestational AgePregnancyPregnancy Trimester, SecondBiomarkersRANK LigandTNFSF11 protein, humanadverse birth outcomesbiomarkerspregnancyRANKL

Identifiers

PMID42363705
PMCPMC13312827

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