Evidence map›Paper›PMID 42363633›Full record

ArticlePain research & management2026

The Association Between Physical Activity and Epigastric Pain: A Mendelian Randomization and Cross-Sectional Study.

Zhongcao Wei, Qian Yang, Yujie Hao, Na Liu, Jinhai Wang, Xin Xing

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PubMed Full text at PMC Publisher
In one paragraph

Article in Pain research & management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhongcao WeiDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China, xjtu.edu.cn.ORCID https://orcid.org/0000-0001-8931-680X
Qian YangDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China, xjtu.edu.cn.ORCID https://orcid.org/0000-0002-6563-7876
Yujie HaoDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China, xjtu.edu.cn.ORCID https://orcid.org/0000-0002-0658-9368
Na LiuDepartment of Gastroenterology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, Hainan Province, China, hainmc.edu.cn.ORCID https://orcid.org/0000-0003-3246-9674
Jinhai WangDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China, xjtu.edu.cn.ORCID https://orcid.org/0000-0003-1365-4727
Xin XingHealth Management Department, The Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China, xjtu.edu.cn.ORCID https://orcid.org/0000-0003-0161-2482

Funding

Key Project of Shaanxi Province 2018ZDXM-SF-046Key Project of Shaanxi Province 2020SF-159
6 · The paper itself

Abstract

backgroundThe relationship between physical activity (PA) and epigastric pain is not well established. This study uniquely combined Mendelian randomization (MR) for causal inference with a cross-sectional analysis for epidemiological validation.

methodsWe performed an MR analysis using inverse variance weighting (IVW) as the primary method. For the cross-sectional study, we analyzed data from the National Health and Nutrition Examination Survey (NHANES), categorizing PA (leisure-time, occupational, and transportation) according to U.S. GUIDELINES:

resultsGenetically predicted walking for pleasure was inversely associated with epigastric pain (IVW OR = 0.966, 95% CI: 0.948-0.985, P = 3.912 × 10

conclusionsThe integration of genetic and observational evidence demonstrates that the effect of PA on epigastric pain is context-dependent. Leisure-time PA is protective, whereas occupation-related PA may increase risk. These findings highlight the context-dependent role of PA in gastrointestinal health.

Indexed as

ExerciseMendelian Randomization AnalysisAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutrition Surveysassociationcross-sectional studyepigastric painMendelian randomizationphysical activity

Identifiers

PMID42363633
PMCPMC13309679

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.