Evidence map›Paper›PMID 42363442›Full record

ArticlePediatric transplantation2026

Antimicrobial Prophylaxis in Solid Organ and Hematopoietic Stem Cell Transplantation: A Survey Among Member Centers of the European Reference Network TransplantChild.

Daniele Donà, Cecilia Liberati, Enrico Aidala, Zivile Bekassy, Anna Bjerre, Victoria Bordon, David Bueno Sanchez, Antonia H M Bouts, Luz Yadira Bravo-Gallego, Valeria Casotti and 63 more

Abstract readMulticenter Study
In one paragraph

Article in Pediatric transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

73 authors.

Daniele DonàDivision of Pediatric Infectious Diseases, Department of Women's and Children's Health, University of Padua, Padua, Italy.ORCID https://orcid.org/0000-0001-7105-2105
Cecilia LiberatiDivision of Pediatric Infectious Diseases, Department of Women's and Children's Health, University of Padua, Padua, Italy.ORCID https://orcid.org/0000-0002-0821-5757
Enrico AidalaPediatric and Congenital Cardiac Surgery, Regina Margherita Children's Hospital, AOU Città Della Salute e Della Scienza di Torino, Turin, Italy.
Zivile BekassyDepartment of Pediatric Nephrology, Skane University Hospital, Lund, Sweden.ORCID https://orcid.org/0000-0002-5942-281X
Anna BjerreDivision of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway.
Victoria BordonPediatric Hematology, Oncology and Stem Cell Transplantation Department, Ghent University Hospital, Ghent, Belgium.ORCID https://orcid.org/0000-0001-8446-0220
David Bueno SanchezPediatric Stem Cell Transplantation Department, La Paz University Hospital, Madrid, Spain.
Antonia H M BoutsDepartment of Pediatric Nephrology, Emma Children's Hospital, Amsterdam University Medical Center, Amsterdam Institute of Infection and Immunity, Amsterdam, the Netherlands.
Luz Yadira Bravo-GallegoLymphocyte Pathophysiology in Immunodeficiencies Group, La Paz Institute of Biomedical Research (IdiPAZ), Center for Biomedical Network Research on Rare Diseases (CIBERER U767), Madrid, Spain.ORCID https://orcid.org/0000-0002-4919-5166
Valeria CasottiPediatric Hepatology, Gastroenterology and Transplantation, Child Health Department, ASST Papa Giovanni XXIII, Bergamo, Italy.
Silvia CatalanoGeneral Surgery 2U, Liver Transplantation Center, Regina Margherita Children's Hospital, AOU Città Della Salute e Della Scienza di Torino, Turin, Italy.
Patricia Costa-ReisPediatric Nephrology and Kidney Transplantation Unit, Pediatrics Department, Santa Maria Hospital, Lisbon University, Lisbon, Portugal.
Ugo CucinottaPediatric Liver Unit, National Reference Center for Rare Pediatric Liver Diseases, Necker-Enfants Malades Hospital, University of Paris, Paris, France.
Dominique DebrayPediatric Liver Unit, National Reference Center for Rare Pediatric Liver Diseases, Necker-Enfants Malades Hospital, University of Paris, Paris, France.
Huib De JongDepartment of Pediatric Nephrology, Erasmus MC Transplant Institute, Sophia Children's Hospital, Rotterdam, the Netherlands.
Francisco De la Cerda-OjedaPediatric Nephrology Unit, Virgen del Rocio University Hospital, Sevilla, Spain.
Olga De la SernaPediatric Lung Transplant Unit, Pediatric Pulmonology Department, La Paz University Hospital, Madrid, Spain.ORCID https://orcid.org/0009-0002-1966-466X
Sandra FerreiraHepatology and Pediatric Liver Transplantation Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Björn FischlerDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, Astrid Lindgren Children's Hospital & CLINTEC, Karolinska Institutet, Stockholm, Sweden.
Luis García GueretaPediatric Cardiology Department, La Paz University Hospital, Madrid, Spain.
Nuria GilDepartment of Pediatric Cardiology, Hospital Gregorio Marañón, Madrid, Spain.
Marta González VincentDepartment of Stem Cell Transplantation, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Ferran Gran-IpiñaPediatric Heart Transplant Unit, Pediatric Cardiology and Pediatric Cardiac Surgery Department, Hospital Vall Hebron, Barcelona, Spain.
Ryszard GrendaDepartment of Nephrology, Kidney Transplantation and Hypertension, The Children's Memorial Health Institute, Warsaw, Poland.
Daniela GrimaPediatrics, Mater Dei Hospital, Msida, Malta.
Uta HerdenDepartment of Visceral Transplantation, University Medical Center Hamburg-Eppendorf, Germany.
Maria Loreto HierroPediatric Hepatology Department, La Paz University Hospital, Madrid, Spain.
Jorge HuertaPediatric Hematology-Oncology Department, Hospital Materno-Infantil Gregorio Marañón, Madrid, Spain.
Timo JahnukainenDepartment of Pediatric Nephrology and Transplantation, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland.
Augustina JankauskienePediatric Center, Institute of Clinical Medicine, Vilnius University, Vilnius, Lithuania.
Piotr KalicińskiDepartment of Pediatric Surgery and Organ Transplantation, Children's Memorial Health Institute, Warsaw, Poland.ORCID https://orcid.org/0000-0003-0555-2229
Karsten KötzDepartment of Pediatrics, the Queen Silvia Children's Hospital, Sahlgrenska University Hospital and Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Region Västra Götaland, Sweden.
Maria Francelina LopesPediatric Surgery and Burn Service, Pediatric Hospital, ULS Coimbra, EPE, Coimbra Academic Clinical Center, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Mercedes Lopez GonzalesPediatric Nephrology Department, Vall D'hebron Research Institute, Vall D'hebron Hospital Campus, Barcelona, Spain.
Álvaro MadridPediatric Nephrology Department, Sant Joan de Deu University Hospital, Barcelona, Spain.
Maria Mercadal-HallyPediatric Hepatology and Liver Transplant Unit, Universitat Autónoma de Barcelona, Vall D'hebron Barcelona Hospital Campus, Barcelona, Spain.
Julia MarsalSCT Unit, Pediatric Cancer Center, Sant Joan de Deu University Hospital, Barcelona, Spain.
Antonio MarzolloPediatric Hematology, Oncology and Stem Cell Transplant Division, Department of Women's and Children's Health, Padua University Hospital, Padua, Italy.
Karin MellgrenDepartment of Pediatric Oncology, Queen Silvia Children Hospital/Sahlgrenska University Hospital, Goeteborg, Sweden.
Natalia Mendoza-PalomarPediatric Infectious Diseases and Immunodeficiencies Unit and Vall D'hebron Research Institute, Vall D'hebron Barcelona Hospital Campus, Barcelona, Spain.
Frauke MutschlerDepartment of Pediatric Kidney, Liver, and Metabolic Diseases, Hannover Medical School, Hannover, Germany.
Michal OdermarskyPediatric Heart Center, Skåne University Hospital, Lund, Sweden.
José María Pérez-Hurtado De MendozaHematology and Hemotherapy Service, Virgen del Rocío University Hospital, Seville, Spain.
Licia PeruzziPediatric Nephrology Unit, Regina Margherita Children's Hospital, AOU Citta Della Salute e Della Scienza di Torino, Turin, Italy.
Andra PietrobattistaHepatology and Liver Transplant Unit, Bambino Gesù Children's Hospitals, IRCCS, Rome, Italy.ORCID https://orcid.org/0000-0002-4426-0395
Michele PinonPediatric Gastroenterology Unit, Regina Margherita Children's Hospital, AOU Città Della Salute e Della Scienza di Torino, Turin, Italy.ORCID https://orcid.org/0000-0001-5077-5531
Agnieszka PrytulaDepartment of Pediatric Nephrology and Rheumatology, Ghent University Hospital, Ghent, Belgium.ORCID https://orcid.org/0000-0001-9551-8758
Esther Boluda RamosPediatric Gastroenterology Intestinal Rehabilitation Unit, La Paz University Hospital, Madrid, Spain.ORCID https://orcid.org/0000-0001-6743-9198
Giusy RanucciDepartment of Pediatrics, IRCCS ISMETT-UPMC Italy, Palermo, Italy.
Jelena RasconCenter for Pediatric Oncology and Haematology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Francesco SaglioPediatric Onco-Hematology Division, Regina Margherita Children's Hospital, Turin, Italy.
Ana Rita SandesPediatric Nephrology and Kidney Transplantation Unit, Pediatrics Department, Santa Maria Hospital, Lisbon University, Lisbon, Portugal.
Marco SciveresHepatology and Liver Transplant Unit, Bambino Gesù Children's Hospitals, IRCCS, Rome, Italy.
Nicolaus SchwerkPediatric Pneumology, Allergology, and Neonatology and German Center for Lung Research (DZL), Hannover Medical School, Hannover, Germany.
Kalid SharifLiver Unit, Birmingham Women's and Children's Hospital, Birmingham, UK.ORCID https://orcid.org/0000-0003-2703-8423
Søren Schwartz SørensenDepartment of Nephrology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Xavier StephenneDivision of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, Cliniques Universitaires Saint Luc, Brussels, Belgium.
Clodagh SweeneyDepartment of Pediatric Nephrology, Children's Health Ireland, Dublin, Ireland.
Ana TexeiraPediatric Nephrology Department, Unidade Local de Saúde de Santo António, Porto, Portugal.
Martin TepelDepartment of Nephrology, Odense University Hospital, Odense, Denmark.
Dominik TurkiewiczDepartment of Pediatrics, Skåne University Hospital, Lund, Sweden.
Inga VainumaeDepartment of Pediatrics, Tartu University Hospital, Tartu, Estonia.
Anita VermaDepartment of Infection Science, Pediatric Liver, GI and Nutrition Center and Mowatlabs, King's College Hospital, London, UK.ORCID https://orcid.org/0000-0002-9231-9363
Håkan WåhlanderPediatric Heart Center, The Queen Silvia Children's Hospital, Sahlgren's University Hospital, University of Gothenburg, Gothenburg, Sweden.ORCID https://orcid.org/0000-0002-4753-3811
Adriana WarringtonDepartment of Child and Adolescent Health, Mater Dei Hospital, Msida, Malta.
Lars WennbergDepartment of Transplantation Surgery, Karolinska University Hospital, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-3313-3374
Susanne WestphalDepartment of Pediatric Nephrology, the Queen Silvia Children Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden.
Brigitte W M WillemseDepartment of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital and University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Tom WolfsDepartment of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, UMC Utrecht, Utrecht, the Netherlands.
Alejandro ZarauzaPediatric Nephrology Department, La Paz-IdiPAZ University Hospital, Madrid, Spain.
Elisa BenettiPediatric Nephrology, Department of Women's and Children's Health, Padua University Hospital, Padua, Italy.ORCID https://orcid.org/0000-0002-8939-6376
Francisco Hernández- OliverosPediatric Surgery Department and Institute for Health Research IdiPAZ, La Paz University Hospital, Madrid, Spain.ORCID https://orcid.org/0000-0002-6998-5229
ERN‐TransplantChild

Funding

EU4Health Programme 101156607
6 · The paper itself

Abstract

backgroundAntimicrobial management in pediatric transplantation lacks standardized international guidelines, and current practices across European transplant centers remain poorly described. This study aimed to evaluate microbiological screening and peri-transplant antimicrobial strategies among centers participating in the European Reference Network on Transplantation in Children (ERN TransplantChild), including both solid organ transplantation (SOT) and hematopoietic stem cell transplantation (HSCT) programs.

methodsBetween December 2022 and February 2023, healthcare professionals within the network completed a structured survey addressing microbiological screening practices and peri-transplant antimicrobial strategies in pediatric transplant recipients.

resultsOf 127 transplant programs invited, 76 (59.8%) responded, including 62 SOT and 14 HSCT programs from 36 centers across 16 European countries. Pre-transplant screening strategies, microbiological methods, and decolonization practices varied substantially between centers. Reported prevalence of methicillin-resistant Staphylococcus aureus and extended-spectrum β-lactamase-producing organisms was below 10% in most programs. In SOT, perioperative prophylaxis varied according to transplanted organ type. Cephalosporins were most commonly used in kidney and heart transplantation, whereas broader-spectrum regimens, including piperacillin-tazobactam and vancomycin, were more frequently adopted in liver, intestinal, and lung transplantation. Postoperative prophylaxis was continued beyond 24 h in most SOT programs. Antifungal prophylaxis was more commonly adopted in liver, intestinal, and lung transplant recipients. In HSCT, antibacterial peri-transplant use was not routinely prescribed in a substantial proportion of programs, particularly in autologous transplantation, whereas antifungals were widely used in allogeneic HSCT.

conclusionsMarked heterogeneity in microbiological screening and peri-transplant antimicrobial strategies across European pediatric transplant centers underscores the need for transplant-specific, evidence-based guidelines distinguishing between SOT and HSCT settings. These findings provide a foundation for the development of shared clinical pathways and harmonized recommendations.

Indexed as

Antibiotic ProphylaxisHematopoietic Stem Cell TransplantationOrgan TransplantationPractice Patterns, Physicians'Anti-Bacterial AgentsChildEuropeHumansSurveys and QuestionnairesAnti-Bacterial Agents

Identifiers

PMID42363442
PMCPMC13490963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.