Evidence map›Paper›PMID 42363246›Full record

ArticleThyroid research2026

Quality of life in hypothyroid subjects treated with levothyroxine: a cross-sectional study.

Hamide Rezaeizade, Motahare Shabestari, Narjes Hazar, Akram Ghadiri-Anari, Marjan Mehrali, Mohammad Salehi-Shadkami, Reyhaneh Azizi

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Article in Thyroid research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Hamide Rezaeizade *Medical School, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Motahare Shabestari *Medical School, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Narjes HazarDiabetes Research Center, Non- Communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Akram Ghadiri-AnariDiabetes Research Center, Non- Communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Marjan MehraliHematology and Oncology Research Center, Non- Communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammad Salehi-ShadkamiAndrology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Reyhaneh AziziDiabetes Research Center, Non- Communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. raihane.azizi@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesHypothyroidism is a disorder characterized by insufficient thyroid hormone production; its manifestations can lead to impaired function and health-related quality of life. This study is aimed to compare the quality of life (QoL) in levothyroxine(LT4)-treated patients with serum thyroid hormone levels equivalent to those of healthy controls. MATERIALS AND

methodsThis cross-sectional investigation enrolled 220 participants, including 110 hypothyroid individuals treated with LT4 as the case group and 110 euthyroid subjects as the controls. Demographic variables (age, sex, marital status, occupation, and education), QoL, and mean thyroid function indices (Thyroid Stimulating Hormone, Triiodothyronine, and Thyroxine) were assessed and compared between the two groups. The QoL was evaluated using the World Health Organization Quality Of Life (WHOQOL) -BREF Questionnaire.

resultsOur findings demonstrated that QoL scores across the subscales of physical health, mental health, social relationship, environment, and overall QoL and general health were significantly lower in the LT4-treated (case) group compared to the healthy (control) group (p < 0.001). Multiple linear regression showed that disease status (B=-18.61, p < 0.001), education level (B = 4.42, p = 0.005), and mean Triiodothyronine (T3)(B = 0.41, p < 0.001) are independent predictors for QoL.

conclusionsPatients on LT4 therapy have a significantly lower QoL despite achieving serum thyroid hormone levels equivalent to those of healthy controls.

Indexed as

EuthyroidHypothyroidismLevothyroxineQuality of lifeThyroid hormoneWHOQOL

Identifiers

PMID42363246
PMCPMC13563808

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