Evidence map›Paper›PMID 42363240›Full record

ArticleThyroid research2026

Cancer-associated fibroblasts in thyroid cancer stroma correlate with tumour progression and desmoplasia: a histopathological study.

Markos Christidis, Andreas C Lazaris, Polyxeni Nicolopoulou-Stamati, Evangelia Baliou, Athanasios Zafeirakis, Georgios Vilaras, Georgia-Eleni Thomopoulou

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Article in Thyroid research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Markos ChristidisDepartment of Pathology, Army Share Fund Hospital, Monis Petraki 10-12, Athens, 11521, Greece. markchristidis@yahoo.com.
Andreas C Lazaris1st Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, Mikras Asias, Building 10, Goudi, 11527, Greece.
Polyxeni Nicolopoulou-Stamati1st Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, Mikras Asias, Building 10, Goudi, 11527, Greece.
Evangelia BaliouDepartment of Pathology, Army Share Fund Hospital, Monis Petraki 10-12, Athens, 11521, Greece.
Athanasios ZafeirakisDepartment of Nuclear Medicine, Army Share Fund Hospital, Monis Petraki 10-12, Athens, 11521, Greece.
Georgios VilarasDepartment of Pathology, Army Share Fund Hospital, Monis Petraki 10-12, Athens, 11521, Greece.
Georgia-Eleni ThomopoulouDepartment of Cytopathology, Attikon University General Hospital, School of Medicine, National and Kapodistrian University of Athens, Rimini 1, Athens, Chaidari, 12461, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AIM AND

objectivesTumour stroma is acknowledged as a fundamental constituent of the tumour microenvironment, which drives cancer progression. Cancer-associated fibroblasts are an integral part of the cancer stroma. However, their role in thyroid cancer is not fully elucidated. The aim of this study is to determine the relationship between the expression of stromal cancer-associated fibroblasts' immunohistochemical biomarkers in thyroid cancer and clinicopathological features of the disease.

methodsEighty-five formalin-fixed paraffin-embedded tissue sections of different thyroid cancer cases were stained with Masson's trichrome, α-smooth muscle actin (α-SMA) and fibroblast activation protein (FAP) and scored based on the extent of the stained area and staining intensity. Statistical analysis was performed to assess any correlation with clinicopathological features.

resultsα-SMA showed a positive correlation with male gender (p = 0.02), tumour size greater than 1 cm (p = 0.0014) and histopathologic features of aggressiveness (p = 0.023). FAP was positively correlated with extent of desmoplasia (p = 0.024). Additionally, stromal desmoplasia was negatively correlated with tumour size greater than 1 cm (p = 0.0082).

conclusionCancer-associated fibroblasts are associated with increased tumour progression and desmoplasia in thyroid cancer.

Indexed as

Cancer-associated fibroblastsDesmoplasiaFAPThyroid cancerTumour microenvironmentα-SMA

Identifiers

PMID42363240
PMCPMC13587427

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