Trial reportBMC pediatrics2026
Effects of a less invasive suction protocol on pain and physiological stability in preterm infants receiving non-ınvasive ventilation: a randomized controlled trial.
Trial report in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07111611 (Effects of Non-Traumatic Nasopharyngeal Suction Technique in Infants During Non-Invasive Ventilation), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Non-Traumatic Nasopharyngeal Suction Technique in Infants During Non-Invasive Ventilation
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-invasive ventilation (NIV) is widely used in preterm infants to reduce ventilator-associated lung injury. However, nasopharyngeal suctioning during NIV is an invasive procedure that may cause pain, stress and physiological instability in preterm infants. This study aimed to compare the effects of less invasive suction protocol and conventional nasopharyngeal suctioning on pain and physiological stability in preterm infants receiving non-invasive ventilation.
methodsThis randomized controlled trial was conducted in a tertiary neonatal intensive care unit. Preterm infants with a gestational age of 32
resultsBaseline demographic and clinical characteristics were comparable between groups. During suctioning, infants in the less invasive suction protocol group had significantly lower HR and higher SpO₂ levels compared to the conventional group (p < 0.05). The proportion of infants with pink skin color was significantly higher in the less invasive suction protocol group. N-PASS pain scores during the procedure were significantly lower in the less invasive suction protocol group (p < 0.05). No significant differences were observed between groups in RR measurements at any time point.
conclusionsThe less invasive suction protocol reduced procedural pain and supported physiological stability in preterm infants receiving NIV. Minimizing airway manipulation may contribute to safer and more developmentally supportive care in neonatal intensive care units.
trial registrationClinicalTrials.gov (NCT07111611), registered on 08 August 2025 (retrospectively registered).
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