Evidence map›Paper›PMID 42363138›Full record

ArticleBMC gastroenterology2026

Colorectal mucinous adenocarcinoma with signet-ring cells: a case report.

Yuan-Sheng Liu, Wei-Ting Zeng, Song-Yan Ma, Hui-Qiong Cao

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Article in BMC gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

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4 authors.

Yuan-Sheng LiuDepartment of Gastroenterology, Huizhou Third People's Hospital, Guangzhou Medical University, Huizhou, Guangdong, China.
Wei-Ting ZengDepartment of Pathology, Huizhou Third People's Hospital, Guangzhou Medical University, Huizhou, Guangdong, China.
Song-Yan MaDepartment of Gastroenterology, Huizhou Third People's Hospital, Guangzhou Medical University, Huizhou, Guangdong, China. 69286280@qq.com.
Hui-Qiong CaoDepartment of Gastroenterology, Huizhou Third People's Hospital, Guangzhou Medical University, Huizhou, Guangdong, China. caohuiq@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn recent years, only a few cases of mucinous adenocarcinoma with signet-ring cell carcinoma (MAC-SRC) have been reported, and detailed endoscopic imaging features remain poorly characterized. This is likely because these tumors are often already at an advanced stage at diagnosis, rendering endoscopic examination infeasible. We herein report a young Asian male diagnosed with sigmoid colon MAC-SRC (60% mucinous adenocarcinoma, 40% signet-ring cell carcinoma). CASE PRESENTATION: A 27-year-old male presented with recurrent vomiting for 20 days. Abdominal computed tomography showed marked thickening of the sigmoid colon wall. Colonoscopy demonstrated luminal stenosis and rigidity, with extensive erosive lesions covered by abundant, difficult-to-irrigate white mucus; the lesion measured 8 cm in length. Biopsy confirmed mucinous adenocarcinoma. The patient underwent left hemicolectomy, and postoperative pathology verified MAC-SRC. Four months after initiating chemotherapy, the patient continues treatment with no changes in lifestyle, diet, or work compared to the pre-illness state.

conclusionsCompared with conventional adenocarcinoma, MAC-SRC in young patients shows distinct clinical features and carries a high risk of missed diagnosis. Colonoscopy with adequate biopsy is essential. This patient initially presented with upper gastrointestinal symptoms, leading to a delay in diagnosis. Timely intervention was initiated following endoscopic detection of mucosal abnormalities and confirmatory biopsy findings. The endoscopic characteristics we describe provide diagnostic evidence for MAC-SRC and have important clinical implications.

Indexed as

Adenocarcinoma, MucinousCarcinoma, Signet Ring CellColorectal NeoplasmsAdultColonoscopyColon, SigmoidHumansMaleTomography, X-Ray ComputedBiopsyCase reportColonoscopyConventional adenocarcinomaMucinous adenocarcinomaMucinous adenocarcinoma with signet-ring cells (MAC-SRC)

Identifiers

PMID42363138
PMCPMC13579756

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