ArticleBMC women's health2026
Elevated urinary succinate in women with symptom-defined overactive bladder without clinically recognized cardiometabolic disease: a cross-sectional study.
Article in BMC women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOveractive bladder (OAB) is a symptom-defined syndrome, and its metabolic correlates remain incompletely understood. This study investigated whether urinary tricarboxylic acid cycle metabolites differ between women with symptom-defined probable OAB and controls without clinically recognized cardiometabolic disease.
methodsIn this cross-sectional clinic-based study, women aged 18 years and older attending a gynecology outpatient clinic were enrolled. Participants with self-reported cardiometabolic disease or related medication use were excluded. Probable OAB was defined by an Overactive Bladder Awareness Tool Version 8 score of 8 or higher. Midstream urine samples were analyzed for succinate and malate by gas chromatography-mass spectrometry and normalized to urinary creatinine. Group comparisons, Spearman correlations, multivariable log-linear regression, sensitivity analyses, and exploratory receiver operating characteristic analyses were performed.
resultsA total of 186 women were included, comprising 81 with OAB and 105 controls. Women with OAB were older, had slightly higher body mass index, higher parity, and were more frequently postmenopausal. Urinary succinate and malate levels were higher in the OAB group. After adjustment for age, body mass index, parity, and menopausal status, OAB remained associated with higher urinary succinate (adjusted geometric mean ratio, 1.69; 95% CI, 1.34-2.12) and malate (1.25; 95% CI, 1.02-1.52). Succinate showed modest exploratory discrimination (AUC, 0.678), whereas malate showed limited discrimination (AUC, 0.560).
conclusionsUrinary succinate was higher in women with symptom-defined probable OAB even after adjustment for major demographic covariates, while the association with malate was weaker. These findings are hypothesis-generating and require confirmation in adequately powered, prospectively phenotyped cohorts with standardized metabolic, dietary, and urinary microbiome assessment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.