ArticleBMC infectious diseases2026
Hepatic, oxidative, and immunological alterations in adults with concomitant Schistosoma mansoni infection and alcohol abuse in an endemic area of Cameroon.
Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundSchistosoma mansoni infection and chronic alcohol consumption are major public health concerns that predominantly affect the liver, yet their combined hepatic effects remain insufficiently understood. This study aimed to investigate the pathophysiological mechanisms associated with this co-exposure in an endemic setting in Cameroon.
methodsA cross-sectional analytical study was conducted in Makenéné, Cameroon, including 310 adults stratified by parasitic status and level of alcohol exposure. Infection was diagnosed using Kato-Katz and POC-CCA assays. Alcohol exposure was assessed using the Alcohol Use Disorders Identification Test (AUDIT). Hematological, liver function, oxidative, inflammatory, and fibrogenic profiles were evaluated.
resultsCompared with alcohol abuse alone, combined S. mansoni infection and alcohol abuse was associated with reduced erythrocyte and platelet indices (p < 0.05), elevated activities of AST (p < 0.001), ALP (p < 0.01), GGT (p < 0.05), AST/ALT ratio (p < 0.001), and protein concentration (p < 0.001). Relative to schistosomiasis alone, the comorbidity was associated with higher ALT and AST (p < 0.01) and GGT (p < 0.05), but lower total protein (p < 0.05). Both schistosomiasis and alcohol abuse, independently, induced oxidative stress, evidenced by increased malondialdehyde levels (p < 0.001) and decreased catalase activity, GSH, and nitrite levels. This oxidative imbalance was exacerbated in co-exposed individuals who exhibited the lowest catalase activity (p < 0.01) and GSH concentration (p < 0.05). The comorbidity was also characterized by the lowest TNF-α levels (p < 0.05) and the highest TGF-β1 levels (p < 0.001). Procollagen type III N-terminal peptide (P3NP) peaked during S. mansoni infection (p < 0.001) but was less expressed during the comorbidity (p < 0.05). Both S. mansoni infection intensity and alcohol abuse correlate positively with transaminases and malondialdehyde, but negatively with nitrite, catalase, and TNF-α. Infection correlates positively with proteins, TGF-β1, IL-10, and P3NP, while alcohol abuse negatively correlates with IL-10 and SOD.
conclusionS. mansoni infection and alcohol abuse comorbidity exacerbates liver injury beyond either condition alone, with increased liver enzymes, oxidative stress, immune imbalance, and fibrogenesis, highlighting the need for integrated public health strategies to reduce liver-related morbidity in endemic settings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.