ArticleBMC microbiology2026
Phage cocktails for the disinfection of carbapenem-resistant Klebsiella pneumoniae on high-touch surfaces in intensive care units.
Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
backgroundCarbapenem-resistant Klebsiella pneumoniae (CRKP) is a major cause of hospital-acquired infections, particularly in intensive care units (ICUs). Chemical disinfectants are widely used for environmental decontamination in ICUs. However, their long-term application is associated with bacterial tolerance, material corrosion, and reduced lifespan of frequently touched surfaces. Environmentally friendly and effective alternative disinfection strategies are therefore urgently needed.
resultsCRKP remained viable on high-touch ICU surfaces for at least 72 h on stainless steel and up to two weeks on cotton fabrics. In liquid culture, high concentrations of phages XDRKpn-1, XDRKpn-2, and the phage cocktail reduced CRKP populations by approximately 4 log units within 12 h. In biofilm inhibition assays, phages XDRKpn-1 and XDRKpn-2 achieved inhibition rates of 78.66% and 64.22% at 10
conclusionsPhages XDRKpn-1 and XDRKpn-2 effectively reduced CRKP contamination on ICU-relevant high-touch surfaces under laboratory conditions, highlighting their potential as a targeted and environmentally friendly alternative or complement to conventional chemical disinfectants. However, further studies are required to validate their efficacy and stability in the complex, real-world ICU environment.
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