Evidence map›Paper›PMID 42362987›Full record

ReviewEye (London, England)2026

Vision-related quality of life in non-neovascular age-related macular degeneration: a protocol for systematic review and meta-analysis.

Guangwen Sun, Dena Zeraatkar, Ryan E K Man, Maryam Ghadimi, João Pedro Lima, Sobha Sivaprasad, Enrico Borrelli, David H Steel, Robyn H Guymer, Tien Yin Wong and 3 more

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Guangwen SunFaculty of Health Sciences, School of Nutrition Sciences, University of Ottawa, Ottawa, ON, Canada.
Dena ZeraatkarDivision of Ophthalmology, Department of Surgery, McMaster University, Hamilton, ON, Canada.
Ryan E K ManSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.ORCID http://orcid.org/0000-0001-5028-605X
Maryam GhadimiDivision of Ophthalmology, Department of Surgery, McMaster University, Hamilton, ON, Canada.
João Pedro LimaDivision of Ophthalmology, Department of Surgery, McMaster University, Hamilton, ON, Canada.
Sobha SivaprasadNIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK.
Enrico BorrelliVita-Salute San Raffaele University, Milan, Italy.ORCID http://orcid.org/0000-0003-2815-5031
David H SteelBioscience Institute, Newcastle University, Newcastle Upon Tyne, UK.
Robyn H GuymerCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-9441-4356
Tien Yin WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Charles C WykoffRetina Consultants of Texas, Houston, TX, USA.
Jinhui MaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Varun ChaudharyDivision of Ophthalmology, Department of Surgery, McMaster University, Hamilton, ON, Canada. vchaudh@mcmaster.ca.ORCID http://orcid.org/0000-0002-9988-4146

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is a progressive retinal disease and a major cause of visual impairment in older adults. Non-neovascular AMD (non-nAMD), the more common phenotype, can substantially impair vision-related quality of life (QoL) even when visual acuity remains relatively preserved. The 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) is the most widely used instrument for assessing vision-related QoL in AMD. However, QoL in non-nAMD has not been systematically synthesised across disease stages and settings. This review aims to summarise vision-related QoL in treatment-naive patients with non-nAMD, examine how QoL varies by disease stage and measurement instrument and identify study-level factors associated with QoL differences. We will search MEDLINE, Embase, EBM Reviews and APA PsycINFO from inception for original studies reporting mean values or mean differences, with corresponding variability, for overall or subscale scores from the NEI-VFQ-25 or other validated vision-related QoL instruments. Two reviewers will independently screen studies, extract data and assess risk of bias using the appropriate Joanna Briggs Institute critical appraisal checklist for analytical cross-sectional studies. Random-effects meta-analyses will be conducted to pool NEI-VFQ-25 composite and subscale scores by non-nAMD stage and, where available, to estimate differences between stages or versus controls. Instrument-specific meta-analyses will be performed for other QoL measures when feasible and standardised metrics will be used to combine instruments assessing similar constructs but using different scales. Meta-regression will explore whether QoL varies with study-level characteristics. The findings will clarify the functional burden of non-nAMD and support future clinical research and trial design.

Indexed as

Macular DegenerationQuality of LifeHumansMeta-Analysis as TopicSurveys and QuestionnairesSystematic Reviews as TopicVisual Acuity

Identifiers

PMID42362987
PMCPMC13538477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.