ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Post-radiotherapy xerostomia and quality of life in head and neck cancer patients.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeRadiotherapy for head and neck cancer frequently results in radiation-induced xerostomia, a chronic symptom that can persist long-term and compromise oral function and survivorship.
methodsA cross-sectional, non-interventional survey was conducted using a mixed recruitment approach (department-based and nationwide online dissemination). Xerostomia prevalence, symptom characteristics, coping strategies, and oral health-related quality of life (OHRQoL) were assessed using a study-specific xerostomia questionnaire and the validated OHIP-G14 instrument. Overall, 253 questionnaires were returned (202 complete and 51 partial), including 163 completed online via LimeSurvey and 39 completed on paper during routine follow-up visits at the tumour clinic of the department.
resultsXerostomia was reported by 90% of respondents; 53.1% described the daily burden as strong/very strong. Patients with xerostomia had significantly worse OHRQoL than those without (mean OHIP-G14 26.7 vs. 17.3; p < 0.001), corresponding to a clinically relevant mean difference of 9.4 points. In multivariable linear regression, xerostomia remained independently associated with worse OHRQoL (B = 8.86, p < 0.001). Functional impairment and oral pain were more pronounced than psychosocial or aesthetic domains, and perceived xerostomia severity correlated with OHIP scores. Commonly used coping strategies included frequent water intake (81%), sugar-free gum/lozenges (46%), saliva substitutes (43%), and home remedies (e.g., oil or tea) (33%); prescription sialogogues were infrequently used (15%) and perceived as less effective.
conclusionPost-radiotherapy xerostomia is highly prevalent and independently associated with clinically meaningful OHRQoL impairment, underscoring the need for optimized counselling and structured supportive care. Management was dominated by low-threshold behavioural strategies, while prescription sialogogues were used by only a minority of respondents and were rated less effective in terms of perceived benefit.
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