Evidence map›Paper›PMID 42362901›Full record

ArticleApplied microbiology and biotechnology2026

Human papillomavirus 18 E6-specific Affibody inhibits cervical cancer cell proliferation and induces apoptosis.

Haiyan Dong, Jing Zhang, Le Wu, Xi Zhang, Jun Chen, Wangqi Du, Saidu Kamara, Shanli Zhu, Lifang Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied microbiology and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haiyan Dong *Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Jing Zhang *Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Le WuDepartment of Obstetrics and Gynecology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, 325035, China.
Xi ZhangDepartment of Chemotherapy and Radiotherapy, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou City, China.
Jun ChenInstitute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Wangqi DuInstitute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Saidu KamaraInstitute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Shanli ZhuInstitute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035, China. wenzhouzsl@126.com.
Lifang ZhangInstitute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035, China. wenzhouzlf@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human papillomavirus (HPV) 18 E6 oncoprotein drives cervical carcinogenesis by degrading p53, enabling uncontrolled cell proliferation. In this study, we developed novel trans-activator of transcription (TAT)-conjugated Affibody molecules (TAT-Z

Indexed as

ApoptosisCell ProliferationDNA-Binding ProteinsHuman papillomavirus 18Oncogene Proteins, ViralRecombinant Fusion ProteinsUterine Cervical NeoplasmsAnimalsCell Line, TumorEscherichia coliFemaleHeLa CellsHumansMiceTumor Suppressor Protein p53DNA-Binding ProteinsE6 protein, Human papillomavirus type 18Oncogene Proteins, ViralRecombinant Fusion ProteinsTumor Suppressor Protein p53Affibody moleculesCervical cancerHPV18E6p53Targeted therapy

Identifiers

PMID42362901
PMCPMC13572351

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.