Evidence map›Paper›PMID 42362863›Full record

ArticleNature medicine2026

Evaluating the robustness and readiness of large frontier models in health AI applications.

Yu Gu, Jingjing Fu, Xiaodong Liu, Jeya Maria Jose Valanarasu, Noel C F Codella, Reuben Tan, Qianchu Liu, Ying Jin, Sheng Zhang, Jinyu Wang and 22 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Yu GuMicrosoft Research, Health & Life Sciences, Redmond, WA, USA. aiden.yu.gu@gmail.com.ORCID http://orcid.org/0000-0002-1704-1744
Jingjing FuMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.ORCID http://orcid.org/0009-0004-2806-4791
Xiaodong LiuMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.
Jeya Maria Jose ValanarasuMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.
Noel C F CodellaMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.
Reuben TanMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.
Qianchu LiuMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.
Ying JinMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.
Sheng ZhangMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.
Jinyu WangMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.
Rui WangMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.
Lei SongMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.
Guanghui QinMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.ORCID http://orcid.org/0000-0002-3009-8614
Naoto UsuyamaMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.
Cliff WongMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.
Hao ChengMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.
HoHin LeeMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.ORCID http://orcid.org/0000-0002-7378-2379
Praneeth SanapathiMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.
Sarah HiladoMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.ORCID http://orcid.org/0009-0006-4093-2701
Tristan NaumannMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.ORCID http://orcid.org/0000-0003-2150-1747
Javier Alvarez-ValleMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.ORCID http://orcid.org/0000-0003-0906-4177
Jiang BianMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.ORCID http://orcid.org/0000-0002-9472-600X
Mu WeiMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.
Khalil MalikMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.
Lidong ZhouMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.
Jianfeng GaoMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.
Eric HorvitzMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.ORCID http://orcid.org/0000-0002-8823-0614
Matthew P LungrenMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.
Doug BurgerMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.
Eric TopolScripps Research Translational Institute, Scripps Research, La Jolla, CA, USA. etopol@scripps.edu.ORCID http://orcid.org/0000-0002-1478-4729
Hoifung PoonMicrosoft Research, Health & Life Sciences, Redmond, WA, USA. hoifung@microsoft.com.ORCID http://orcid.org/0000-0002-9067-0918
Paul VozilaMicrosoft Research, Health & Life Sciences, Redmond, WA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Large frontier models such as GPT-5 and Gemini have demonstrated remarkable performance in a wide range of health application benchmarks. However, underneath the seemingly promising results lie salient growth areas, especially in cutting-edge frontiers such as multimodal reasoning. Here we systematically apply and integrate a series of adversarial stress tests to assess the robustness of flagship models and health benchmarks. Our study reveals prevalent brittleness in the presence of simple adversarial transformations: leading systems can guess the correct answer even with key inputs removed yet may get confused by the slightest prompt alterations while fabricating convincing but flawed reasoning traces. Using clinician-guided rubrics, we demonstrate that popular health benchmarks vary widely in what they truly measure. Our study reveals considerable gaps between benchmark performance and the robustness evidence needed to support claims about multimodal medical reasoning in health applications.

Indexed as

Artificial IntelligenceModels, TheoreticalBenchmarkingHumans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.