Evidence map›Paper›PMID 42362746›Full record

ArticleArchives of toxicology2026

Deficient arsenic methylation and global proteomic reprogramming in human keratinocytes during arsenic-induced skin carcinogenesis.

Alexandra N Nail, Mayukh Banerjee, Manting Xu, Caitlin H Reynolds, Miroslav Stýblo, Peter H Cable, Daniel W Wilkey, Michael L Merchant, Ana P Ferragut Cardoso, Shelia D Thomas and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alexandra N Nail *Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.ORCID http://orcid.org/0000-0002-8008-3891
Mayukh Banerjee *Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.ORCID http://orcid.org/0000-0003-3028-1192
Manting XuDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.ORCID http://orcid.org/0009-0008-5953-0045
Caitlin H ReynoldsDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.
Miroslav StýbloDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hil, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-6764-1900
Peter H CableDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hil, Chapel Hill, NC, USA.
Daniel W WilkeyCenter for Integrative Environmental Health Sciences, University of Louisville, Louisville, KY, USA.ORCID http://orcid.org/0000-0001-7491-7696
Michael L MerchantCenter for Integrative Environmental Health Sciences, University of Louisville, Louisville, KY, USA.ORCID http://orcid.org/0000-0003-4128-4057
Ana P Ferragut CardosoDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.ORCID http://orcid.org/0000-0001-6689-7437
Shelia D ThomasDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.ORCID http://orcid.org/0000-0002-1892-3765
J Christopher StatesDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA. jcstates@louisville.edu.ORCID http://orcid.org/0000-0003-4717-4422

Funding

University of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Amanda Jo LeBlanc · 2020 to 2026
$10.0M
UOFL ENVIRONMENTAL HEALTH SCIENCES TRAINING PROGRAMT32ES011564 · NIEHS · UNIVERSITY OF LOUISVILLE · PI David W Hein, John Pierce Wise · 2004 to 2026
$7.1M
Mechanism for arsenic induced carcinogenesisR01ES027778 · NIEHS · UNIVERSITY OF LOUISVILLE · PI J CHRISTOPHER STATES · 2017 to 2026
$4.3M
University of Louisville Cancer Education ProgramR25CA134283 · NCI · UNIVERSITY OF LOUISVILLE · PI HEIN, DAVID W, KIDD, LA CREIS RENEE · 2011 to 2022
$3.1M
American Cancer Society PF-23-1153675-01-DMCNCI NIH HHS R25 CA134283NCI NIH HHS R25CA134283NIEHS NIH HHS P30 ES030283NIEHS NIH HHS P30ES030283NIEHS NIH HHS R01 ES027778NIEHS NIH HHS R01ES027778NIEHS NIH HHS T32 ES011564NIEHS NIH HHS T32ES011564
6 · The paper itself

Abstract

Chronic inorganic arsenic (iAs) exposure affects > 220 million people worldwide and skin cancer is a hallmark of long-term iAs exposure. Limited information exists regarding arsenic methylation by human keratinocytes and how methylation influences skin carcinogenesis. Inorganic arsenite (iAs

Indexed as

ArsenicArsenic metabolismArsenite methyltransferaseHuman keratinocytesProteomics

Identifiers

PMID42362746
PMCPMC13546112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.