ArticleInternational journal of obesity (2005)2026
Linking circulating chemerin and adiponectin to lipoprotein subclasses measured by
Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
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Abstract
BACKGROUND/
objectivesAssociations between adiponectin and chemerin with the most clinically established lipid parameters for assessing cardiovascular risk - LDL-cholesterol, HDL-cholesterol, and triglycerides-are well documented. Since lipoproteins are heterogeneous with respect to size, density, and chemical composition, the examination of their subclasses could help to elucidate the complex interactions between adipokines and lipid metabolism. SUBJECTS/
methodsLipoprotein subclasses were quantified by nuclear magnetic resonance spectroscopy in samples from 3199 participants of the Study of Health in Pomerania (SHIP-TREND-0). Associations between adiponectin/chemerin and lipoprotein subclasses were analyzed using appropriately adjusted linear regression models.
resultsThe analyses revealed a wide range of statistically significant associations between adiponectin/chemerin and lipoprotein subclasses, that were primarily in opposite directions. Higher adiponectin concentrations were, for example, related to a lower particle number and a lower cholesterol, phospholipid and triglyceride content in atherogenic small, dense LDL-particles, while positive associations were observed for chemerin.
conclusionsOur highly consistent results demonstrate that high adiponectin was associated with a favorable, anti-atherogenic lipoprotein profile, whereas the opposite was observed for chemerin. Whether these cross-sectional associations reflect causal mechanisms or alternatively, shared underlying metabolic processes, must be clarified by experimental and longitudinal research.
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