ArticleNature communications2026
dITP-induced remodeling activates the filamentous effector complex in Kongming anti-phage defense.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Several antiviral immune systems based on nucleotide signaling have been identified in bacteria. One of them is the Kongming system, which includes an effector complex (KomBC), composed of a non-canonical purine NTP pyrophosphatase (KomB) and a SIR2 domain-containing protein (KomC). The Kongming system is activated by an atypical signaling nucleotide, dITP, generated upon phage infection. Here, we use structural and functional analyses to show that KomBC assembles into a helical filament, built from vertically stacked 4:4 KomB-KomC repeating units. Binding of dITP to KomB initiates progressive conformational rearrangements within the filament, ultimately remodeling the filament into a distinct architecture in which KomC adopts an active conformation with NADase activity. We further identify a key residue potentially involved in the acquisition of NADase activity in SIR2 family proteins. Thus, our results elucidate the activation mechanism of KomBC, revealing a distinct mode of effector activation by a signaling molecule.
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