Evidence map›Paper›PMID 42362493›Full record

ArticleHLA2026

Full-Length Next-Generation Sequencing of 11 HLA Loci of More Than 1000 Individuals From Clinical Cohorts in East and West Africa.

Yvonne V Rosario, Aviva Geretz, Lakshmi Rani Iyer, Philip K Ehrenberg, Alýa Tyson, Hannah Kibuuka, Fred Wabwire-Mangen, Lucas Maganga, Abdulwasiu Tiamiyu, Jonah Maswai and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HLA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Yvonne V RosarioU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.ORCID https://orcid.org/0009-0009-7883-9336
Aviva GeretzU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Lakshmi Rani IyerU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Philip K EhrenbergU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Alýa TysonU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Hannah KibuukaMakerere University Walter Reed Program, Kampala, Uganda.
Fred Wabwire-MangenMakerere University Walter Reed Program, Kampala, Uganda.
Lucas MagangaU.S. Military HIV Research Program, Walter Reed Army Institute of Research Africa, Nairobi, Kenya.
Abdulwasiu TiamiyuU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Jonah MaswaiU.S. Military HIV Research Program, Walter Reed Army Institute of Research Africa, Nairobi, Kenya.
Josphat KosgeiHJF Medical Research International, Kericho, Kenya.
Frederick SaweHJF Medical Research International, Kericho, Kenya.
Gary R MatyasU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Merlin L RobbU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Julie A AkeU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Rasmi ThomasU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.ORCID https://orcid.org/0000-0002-2116-2418

Funding

Henry M. Jackson Foundation for the Advancement of Military Medicine Inc and U.S. Department of War through the Walter Reed Army Institute of Research HT94252420020Henry M. Jackson Foundation for the Advancement of Military Medicine Inc and U.S. Department of War through the Walter Reed Army Institute of Research HT94252430004Henry M. Jackson Foundation for the Advancement of Military Medicine Inc and U.S. Department of War through the Walter Reed Army Institute of Research W81XWH-18-2-0040
6 · The paper itself

Abstract

HLA loci have been implicated in several diseases, including HIV-1, from different world populations. It is necessary to characterise HLA allele variation at the population level prior to investigating associations linked to human diseases. In global databases, limited high-resolution HLA allele types generated by next-generation sequencing (NGS) have been described for populations from African countries. We sought to expand our NGS-based HLA genotyping database to include a total of 1023 participants from multiple clinical studies using a contiguous full-length gene sequencing approach. Collectively we describe HLA genotypes of individuals from Kenya (N = 375), Uganda (N = 338), Nigeria (N = 139), Tanzania (N = 89) and Mozambique (N = 82). Overall, we identified 362 unique HLA alleles across 11 loci with the most frequent at each locus being A*02:01:01, B*53:01:01, C*04:01:01, C*06:02:01, DPA1*01:03:01, DPB1*01:01:01, DQA1*01:02:01, DQB1*06:02:01, DRB1*15:03:01, DRB3*02:02:01, DRB4*01:03:01 and DRB5*01:01:01. A total of 24 novel alleles (HLA-A (2), B (1), C (1), DPA1 (4), DPB1 (6), DQA1 (3), DRB1 (6) and DRB3 (1)) were identified, including 3 (C*07:1218, DQA1*01:190 and DPB1*1820:01) with non-synonymous changes affecting the peptide binding groove of HLA molecules. This expansion of NGS based HLA data at the African population level will improve our understanding of human genetic variation and provide insights for disease association, vaccine development and targeted personalised therapies.

Indexed as

High-Throughput Nucleotide SequencingHIV InfectionsHLA AntigensAllelesGene FrequencyGenotypeHistocompatibility TestingHumansHLA AntigensHIV‐1 cohortsHLAKenyaMozambiqueNGSNigeriaTanzaniaUganda

Identifiers

PMID42362493
PMCPMC13309289

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.