Evidence map›Paper›PMID 42362487›Full record

ArticleEuropean journal of pain (London, England)2026

Embodied Interoception Questionnaire (Intero-10): Development, Validation, and Application in People With Neuropathic Chronic Pain.

Ana Mércia Fernandes, Vinicius D de Oliveira, Carolina C Dos Santos, Samantha K Millard, Jorge A M P Júnior, Marcell M Barbosa, Pedro N Martins, Suzana C Nogueira, Maercio M Alves, Pedro H M da Cunha and 13 more

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pain (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Ana Mércia FernandesPain Center, Department of Neurology, University of São Paulo, São Paulo, Brazil.
Vinicius D de OliveiraPain Center, Department of Neurology, University of São Paulo, São Paulo, Brazil.
Carolina C Dos SantosPain Center, Department of Neurology, University of São Paulo, São Paulo, Brazil.
Samantha K MillardDepartment of Health Science and Technology, Faculty of Medicine, Center for Neuroplasticity and Pain (CNAP), Aalborg University, Aalborg, Denmark.
Jorge A M P JúniorPain Center, Department of Neurology, University of São Paulo, São Paulo, Brazil.
Marcell M BarbosaPain Center, Department of Neurology, University of São Paulo, São Paulo, Brazil.
Pedro N MartinsFaculty of Medicine of the Federal University of Juiz de Fora, Juiz de Fora, Brazil.
Suzana C NogueiraPain Center, Department of Neurology, University of São Paulo, São Paulo, Brazil.
Maercio M AlvesCenter for Mathematics, Computation and Cognition, Federal University of ABC, São Paulo, Brazil.
Pedro H M da CunhaPain Center, Department of Neurology, University of São Paulo, São Paulo, Brazil.
Danielle C FonsecaLaboratory of Nutrition and Metabolic Surgery of the Digestive System, LIM 35, Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil.
Luccas S LaFerreiraDivision of Urology, Department of Surgery, University of São Paulo School of Medicine, São Paulo, Brazil.
Paulo R Santos-SilvaMovement Studies Laboratory, Department of Orthopedics and Traumatology, University of São Paulo School of Medicine, São Paulo, Brazil.
Nayara S CarvalhoDepartment of Gastroenterology, University of São Paulo, São Paulo, Brazil.
Vinícius C IamontiDivision of Pneumology, Instituto do Coração, University of São Paulo School of Medicine, São Paulo, Brazil.
Celso R F CarvalhoDepartment of Physical Therapy, University of São Paulo School of Medicine, São Paulo, Brazil.
Camila S DaleDepartment of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Gabriel T KubotaPain Center, Department of Neurology, University of São Paulo, São Paulo, Brazil.
Lin T YengPain Center, Department of Neurology, University of São Paulo, São Paulo, Brazil.
Manoel J TeixeiraPain Center, Department of Neurology, University of São Paulo, São Paulo, Brazil.
Abrahão F BaptistaCenter for Mathematics, Computation and Cognition, Federal University of ABC, São Paulo, Brazil.
Interoception Study Group
Daniel Ciampi de AndradePain Center, Department of Neurology, University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-3411-632X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmbodied interoception refers to the perception of the body's state and is a multidimensional cognitive process. Pain experience feeds interoceptive networks with information from the state of the body and the subjective experience of pain would be influenced by an individual's trait embodied interoceptive profile.

methodsHere we developed and validated the Intero-10, a questionnaire designed to evaluate embodied interoception based on trait interoceptive channels in healthy adults (n = 381) and latter assessed how it relates to neuropathic pain features (n = 86) as a pilot exploratory assessment. The relationship between trait and state interoceptive responses was examined during experimentally evoked interoceptive psychophysicsal tasks, specific to each interoceptive channel.

resultsTrait and state interoceptive scores were correlated only for affective-emotional components (unpleasantness, p < 0.05), but not for intensity ratings, suggesting that the negative valence of momentary lived experience is more stable over time than intensity estimations. The Intero-10 final version included both embodied interoceptive perception intensity (heartbeat, heat, itching, dyspnea, sleep, muscle fatigue and anguish) and unpleasantness (heartbeat, dyspnea and nausea) domains. Intero-10 demonstrated adequate content validity, good internal consistency (Cronbach's α = 0.81), good reliability (> 0.75) and a single-factor structure. Patients with neuropathic pain completed the Intero-10 alongside standard pain, mood, sleep and quality of life assessments. Embodied interoception scores correlated with mood and quality of life and partially mediated the correlation between pain interference and quality of life (β = -0.0093).

conclusionSpecific assessment of embodied interoceptive channels may broaden our current assessment of people with chronic pain and of those at risk to develop it. SIGNIFICANCE STATEMENT: This study introduces the Embodied Interoception Questionnaire (Intero-10), a novel tool to assess how individuals perceive bodily states across distinct interoceptive channels. By capturing both sensory and affective dimensions of interoception, the instrument provides a structured approach to investigate trait-state relationships. Its application in neuropathic chronic pain offers preliminary evidence that embodied interoceptive experience can be systematically quantified, opening new avenues for understanding individual variability and for developing targeted interventions in pain management.

Indexed as

Chronic PainInteroceptionNeuralgiaAdultAgedFemaleHumansMaleMiddle AgedPain MeasurementReproducibility of ResultsSurveys and QuestionnairesYoung Adultinteroceptionpainpsychometryquestionnairevalidation

Identifiers

PMID42362487
PMCPMC13309290

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.