Evidence map›Paper›PMID 42362374›Full record

ArticleeNeuro2026

Reduced SuM Activation Accompanies Impaired Social Novelty Recognition in Mouse Models of Neurodevelopmental Disorders.

Raymond Maejima, Yuki Ito, Jun Motoyama

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Raymond MaejimaLaboratory of Developmental Neurobiology, Graduate School of Brain Science, Doshisha University, Kyotanabe, Kyoto 610-0394, Japan.
Yuki ItoOrganization of Advanced Research and Education, Doshisha University, Kyotanabe, Kyoto 610-0394, Japan.
Jun MotoyamaLaboratory of Developmental Neurobiology, Graduate School of Brain Science, Doshisha University, Kyotanabe, Kyoto 610-0394, Japan jmotoyam@mail.doshisha.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Social novelty recognition-the ability to distinguish between familiar and unfamiliar individuals-is frequently disrupted in neurodevelopmental disorders, including those resulting from early-life stress and autism spectrum disorder (ASD). The supramammillary nucleus (SuM) has been implicated as a key region involved in processing novelty-related information and associated with hippocampal CA2 activity; however, whether SuM dysfunction occurs in neurodevelopmental disorder models with impaired social novelty recognition remains unclear. Here, we examined c-Fos expression in the SuM, CA2, and dentate gyrus (DG) following exposure to a novel conspecific in male mice from two models: maternal separation (MS) mice representing early-life stress and

Indexed as

Autism Spectrum DisorderNeurodevelopmental DisordersRecognition, PsychologySocial BehaviorAnimalsCalcium-Binding ProteinsDisease Models, AnimalKisspeptinsMaleMaternal DeprivationMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsProto-Oncogene Proteins c-fosReceptors, G-Protein-CoupledCalcium-Binding ProteinsCAPS2 protein, mouseKisspeptinsNerve Tissue ProteinsProto-Oncogene Proteins c-fosReceptors, G-Protein-CoupledCaps2 deficiencyGPR54maternal separationmousesocial novelty recognitionSuM

Identifiers

PMID42362374
PMCPMC13349467

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.