Evidence map›Paper›PMID 42362150›Full record

ArticleJHEP reports : innovation in hepatology2026

Global trends in national alcohol control policies between 2010 and 2019.

Hyundam Gu, Eduardo Fuentes-López, Francisco Idalsoaga, David Marti-Aguado, Patrick S Kamath, Ashwani K Singal, Ramon Bataller, Marco Arrese, Leire Agirre-Garrido, Trenton M White and 4 more

Abstract read
In one paragraph

Article in JHEP reports : innovation in hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Hyundam GuDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Eduardo Fuentes-LópezDepartamento de Ciencias de La Salud, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Francisco IdalsoagaDepartmento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Observatorio Multicéntrico de Enfermedades Gastrointestinales, OMEGA, Santiago, Chile; Department of Medicine, Division of Gastroenterology, Western University, London Health Sciences Center, London, Ontario, Canada.
David Marti-AguadoDigestive Disease Department, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
Patrick S KamathDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Ashwani K SingalDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA.
Ramon BatallerLiver Unit, Hospital Clinic, Barcelona, Spain.
Marco ArreseDepartmento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Observatorio Multicéntrico de Enfermedades Gastrointestinales, OMEGA, Santiago, Chile.
Leire Agirre-GarridoBarcelona Institute for Global Health (ISGlobal), Hospital Clinic, University of Barcelona, Barcelona, Spain.
Trenton M WhiteBarcelona Institute for Global Health (ISGlobal), Hospital Clinic, University of Barcelona, Barcelona, Spain; CUNY Graduate School of Public Health and Health Policy (CUNY SPH), New York, NY, USA.
Jeffrey V LazarusBarcelona Institute for Global Health (ISGlobal), Hospital Clinic, University of Barcelona, Barcelona, Spain; CUNY Graduate School of Public Health and Health Policy (CUNY SPH), New York, NY, USA.
Frank MurrayDepartment of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
Juan Pablo ArabDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA; Departmento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Observatorio Multicéntrico de Enfermedades Gastrointestinales, OMEGA, Santiago, Chile. Electronic address: juanpablo.arab@vcuhealth.org.
Luis Antonio DíazDepartmento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Observatorio Multicéntrico de Enfermedades Gastrointestinales, OMEGA, Santiago, Chile; MASLD Research Center, Division of Gastroenterology and Hepatology, University of California San Diego, San Diego, CA, USA. Electronic address: luisdiazpiga@gmail.com.

Funding

Integrated therapies for alcohol use and ALD (ITAALD) Network -UofL Clinical CenterU01AA026980 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN, Ashwani K Singal · 2018 to 2026
$2.9M
NIAAA NIH HHS U01 AA026980
6 · The paper itself

Abstract

BACKGROUND &

aimsAlcohol is a leading global risk factor for more than 200 diseases, premature death, and disability. We aimed at updating the Alcohol Preparedness Index (API) to map global and regional policy trends between 2010 and 2019.

methodsWe compiled policy data from 141 countries from the World Health Organization Global Information System on Alcohol and Health and scored five domains: national policy frameworks; production, pricing, and taxation; marketing and availability; drink-driving countermeasures; and monitoring and surveillance. The primary endpoint was the percentage change in API between 2010 and 2019. We summarized trends by region and explored potential variables that explain these trends with an adjusted regression model.

resultsBy 2019, fewer than 25% of countries had a strong national alcohol plan (defined as a written national policy accompanied by a formal action plan for its implementation), whereas 40% had none. Production, pricing, and taxation showed the clearest increase (27% in 2010 and 78% in 2019). Monitoring and surveillance reached strong levels at 47.5%. The median API increased from 57.0 (39.0-82.0) in 2010 to 74.8 (58.3-83.5) in 2016, remaining above baseline in 2019 at 67.8 (51.2-83.8). Larger population size negatively correlated with API change (β = -19.1, p <0.05). Human Development Index and alcohol per capita consumption were not significantly associated with API change.

conclusionsFrom 2010 to 2019, preparedness on alcohol policy increased globally, though progress remained uneven across domains and regions. These findings highlight persistent policy gaps and support the prioritization of evidence-based interventions aligned with the SAFER framework. Future efforts should focus on translating policy presence into implementation, with particular attention to domains most strongly linked to alcohol-associated liver disease outcomes. IMPACT AND IMPLICATIONS: Despite the well-established harms of alcohol, global trends in alcohol policy preparedness remain poorly characterized. Using the validated Alcohol Preparedness Index across 141 countries, we demonstrate meaningful but uneven global progress between 2010 and 2019, with gains concentrated in taxation and monitoring domains, whereas national planning and marketing controls lagged, particularly in low-income regions. These findings are directly relevant to policymakers and public health authorities, as stronger alcohol policy environments have previously been linked to lower rates of alcohol-associated liver disease, hepatocellular carcinoma, and cardiovascular mortality. Within the limitations of an ecological study design, this work provides a practical roadmap for identifying policy gaps and prioritizing interventions aligned with the WHO SAFER framework to reduce the global burden of alcohol-related disease.

Indexed as

Alcohol-associated liver diseaseAlcoholic liver diseaseAlcohol use disorderCirrhosisEthanolNeoplasms

Identifiers

PMID42362150
PMCPMC13544381

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.