Evidence map›Paper›PMID 42361581›Full record

ArticleThe Journal of surgical research2026

Obesity Attenuates the Association Between the Modified Five-Item Frailty Score and Mortality in Septic Surgical Patients.

Bradley Butsch, Maryn Montgomery, Shachi Srivatsa, Courtney Collins, Patrick J Kennedy, Brett Tracy, John Loftus, Jon Wisler, Anahita Jalilvand

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of surgical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bradley ButschDivision of Trauma, Critical Care, and Burns, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Maryn MontgomeryDivision of Trauma, Department of Surgery, Critical Care and Burn, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Shachi SrivatsaDivision of Trauma, Department of Surgery, Critical Care and Burn, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Courtney CollinsDivision of Trauma, Department of Surgery, Critical Care and Burn, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Patrick J KennedyDivision of Trauma, Department of Surgery, Critical Care and Burn, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Brett TracyDepartment of Surgery, New York University Grossman School of Medicine, New York, New York.
John LoftusDivision of Trauma, Department of Surgery, Critical Care and Burn, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Jon WislerDivision of Trauma, Department of Surgery, Critical Care and Burn, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Anahita JalilvandDivision of Trauma, Department of Surgery, Critical Care and Burn, The Ohio State University Wexner Medical Center, Columbus, Ohio. Electronic address: anahita.jalilvand@osumc.edu.

Funding

Analyzing the long-term effects of DNA methylation meditated immunosuppression following sepsisR35GM150968 · NIGMS · OHIO STATE UNIVERSITY · PI Jon R Wisler · 2023 to 2026
$1.6M
The impact of obesity on neutrophil swarming in septic surgical patientsK08GM157658 · NIGMS · OHIO STATE UNIVERSITY · PI Anahita Jalilvand · 2024 to 2026
$572k
NIGMS NIH HHS K08 GM157658NIGMS NIH HHS L30 GM155912NIGMS NIH HHS R35 GM150968
6 · The paper itself

Abstract

introductionObesity is an independent predictor of mortality in septic surgical patients, likely associated with underlying physiologic frailty, measured by the modified 5-item frailty index (mFI-5). This study aimed to determine the prevalence of frailty among obese and nonobese surgical patients and evaluate the impact of frailty on mortality in these populations.

methodsWe performed a single-center retrospective cohort study of surgical intensive care unit patients admitted with sepsis (sequential organ failure assessment, SOFA ≥2). Individual mFI-5 scores (range 0-5) were calculated and the prevalence of prefrailty (mFI <2), moderate-frailty (mFI = 2), and severe-frailty (mFI ≥3) across body mass index (BMI) categories (underweight, nonobese, class I-III obesity) was compared. BMI <18.5 kg/m

resultsSevere frailty was highly associated with increasing BMI class, occurring in 37% of morbidly obese patients versus 19% of nonobese patients (P < 0.005). Increasing BMI independently predicted moderate-to-severe frailty (odds ratio [OR]: 1.04, 95% confidence interval [CI]: 1.02-1.05). Frailty significantly increased 90-day mortality in nonobese patients (17.4% versus 36.4%, P < 0.005) but not in obese patients (34% versus 35%). Nonfrail nonobese patients demonstrated superior 90-day-survival.

conclusionsObesity is highly associated with higher mFI-5 scores, though its prognostic impact appears attenuated in obese versus nonobese cohorts, suggesting the need for more discriminatory frailty tools in the obese population.

Indexed as

FrailtyObesitySepsisAgedAged, 80 and overBody Mass IndexFemaleHumansMaleMiddle AgedObesity ParadoxPrevalenceRetrospective StudiesRisk FactorsAcute care surgeryFrailtyObesitySepsisSurgical sepsis

Identifiers

PMID42361581
PMCPMC13477640

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.