Evidence map›Paper›PMID 42361185›Full record

ArticleScience advances2026

Single-cell heterogeneity in ribosome levels and protein synthesis during nutrient starvation is driven by cAMP signaling.

Zhihui Lyu, Jacques Augenstreich, Volker Briken, Abhyudai Singh, Matteo Mori, Terence Hwa, Jiqiang Ling

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhihui LyuDepartment of Cell Biology and Molecular Genetics, The University of Maryland, College Park, MD 20742, USA.ORCID 0009-0006-8781-5983
Jacques AugenstreichDepartment of Cell Biology and Molecular Genetics, The University of Maryland, College Park, MD 20742, USA.
Volker BrikenDepartment of Cell Biology and Molecular Genetics, The University of Maryland, College Park, MD 20742, USA.ORCID 0000-0001-5830-6107
Abhyudai SinghDepartment of Electrical and Computer Engineering and Biomedical Engineering, University of Delaware, Newark, DE 19716, USA.ORCID 0000-0002-1451-2838
Matteo MoriDepartment of Physics, University of California at San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-6263-8021
Terence HwaDepartment of Physics, University of California at San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-1837-6842
Jiqiang LingDepartment of Cell Biology and Molecular Genetics, The University of Maryland, College Park, MD 20742, USA.ORCID 0000-0003-4466-8304

Funding

Regulation and Physiological Roles of Translational FidelityR35GM136213 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI LING, JIQIANG · 2020 to 2024
$2.0M
Generalized fluctuation test for deciphering phenotypic switching within cell populationsR35GM148351 · NIGMS · UNIVERSITY OF DELAWARE · PI Abhyudai Singh · 2023 to 2026
$1.6M
NIGMS NIH HHS R35 GM136213NIGMS NIH HHS R35 GM148351
6 · The paper itself

Abstract

Ribosomes are central to protein synthesis and a frequent target for antibiotics. In fast-growing bacteria, the ribosome content is proportional to the growth rate; how ribosomes and protein synthesis are regulated during nutrient starvation remains poorly understood, particularly in single cells. To address this, we fluorescently labeled ribosomal proteins (RPs) in

Indexed as

Cyclic AMPNutrientsProtein BiosynthesisRibosomesSignal TransductionSingle-Cell AnalysisBacterial ProteinsGene Expression Regulation, BacterialProteomicsRibosomal ProteinsSalmonellaBacterial ProteinsCyclic AMPRibosomal Proteins

Identifiers

PMID42361185
PMCPMC13308603

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.